Fabrication of biodegradable thin film stents of magnesium alloys by magnetron sputtering

磁控溅射法制备可生物降解镁合金薄膜支架

基本信息

批准号：
130702553
负责人：
Professor Dr.-Ing. Eckhard Quandt
金额：
--
依托单位：
Lehrstuhl für Anorganische Funktionsmaterialien
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2009
资助国家：
德国
起止时间：
2008-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/130702553?language=en
关键词：
Fabrication biodegradable thin film stents

项目摘要

The proposal is planed as a follow-up of the project Fabrication of biodegradable thin film stents made of magnesium alloys by magnetron sputtering. It describes the fabrication and characterization of planar, freestanding, structured thin films of biodegradable magnesium based alloys fabricated by magnetron sputtering and by photolithographic methods, as well as the development of suitable joining technologies for the production of stents and the characterization of these components by fatigue tests. Biodegradable materials form a group with increasing importance in the field of implant materials, which are applied where a permanent implant is not required or even disadvantageous, e.g. for fixation of bone fractures or treatment of children with stents who cannot get permanent implants due to their non-terminated growth.When using magnesium based alloys as biodegradable implant material, one challenge is the local control of the dissolution behaviour (corrosion). Many conventional alloys which are prepared by casing techniques show on the one hand a very localized dissolution and on the other hand a dissolution that proceeds with a too high rate which leads to an impairment of the implant's functionality and also might lead to a damage of the surrounding tissue. In the previous project a well-directed dissolution of the material was intended to be achieved by multilayer systems and gradient layers. It was shown that this approach is not feasible. However, it could also be shown that the dissolution of the magnetron deposited alloys was much more homogeneous compared to cast alloys. Due to these reasons the focus of this proposal is the identification of a suitable alloy which on the one hand does not contain any alloying elements that are harmful to the human metabolism and on the other hand shows a suitable dissolution behaviour in the human body while having a sufficient ductility to be implanted without difficulties at the same time. Within the scope of this project the fatigue behaviour of suitable alloys shall be investigated additionally in order to be able to make a statement about the mechanical behaviour in a corroded state.

该提案计划作为对镁质合金制成的可生物降解薄膜支架的项目制造的随访。它描述了平面，独立的，结构化的薄膜的制造和表征，这些薄膜的可生物降解镁基于磁铁溅射和光刻方法制造的合金，以及开发合适的连接技术来生产支架以及通过疲劳测试来表征这些成分。可生物降解的材料形成了一个在植入物材料领域越来越重要的群体，这些材料在不需要永久性植入物甚至不利的地方应用，例如为了固定骨骨折或因其非终止生长而无法获得永久性植入物的支架的儿童治疗。当将基于镁的合金作为可生物降解的植入物材料时，一个挑战是局部控制溶解行为（腐蚀）。许多通过套管技术制备的常规合金一方面显示出非常局部的溶解，另一方面是溶解的溶解度，其速率过高，从而导致植入物的功能受损，并可能导致周围组织的损害。在上一个项目中，材料的指导溶解旨在通过多层系统和梯度层实现。结果表明，这种方法是不可行的。但是，也可以证明，与铸造合金相比，木磁部沉积合金的溶解更为均匀。由于这些原因，该提案的重点是鉴定合适的合金，一方面，该合金不包含对人类代谢有害有害的任何合金元素，另一方面显示出适当的溶解行为，同时具有足够的延展性，可以同时将其植入。在该项目的范围内，应另外研究合适的合金的疲劳行为，以便能够对腐蚀状态下的机械行为发表声明。