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Fabrication of biodegradable thin film stents of magnesium alloys by magnetron sputtering

磁控溅射法制备可生物降解镁合金薄膜支架

基本信息

批准号：
130702553
负责人：
Professor Dr.-Ing. Eckhard Quandt
金额：
--
依托单位：
Lehrstuhl für Anorganische Funktionsmaterialien
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2009
资助国家：
德国
起止时间：
2008-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/130702553?language=en
关键词：
Fabrication biodegradable thin film stents

项目摘要

The proposal is planed as a follow-up of the project Fabrication of biodegradable thin film stents made of magnesium alloys by magnetron sputtering. It describes the fabrication and characterization of planar, freestanding, structured thin films of biodegradable magnesium based alloys fabricated by magnetron sputtering and by photolithographic methods, as well as the development of suitable joining technologies for the production of stents and the characterization of these components by fatigue tests. Biodegradable materials form a group with increasing importance in the field of implant materials, which are applied where a permanent implant is not required or even disadvantageous, e.g. for fixation of bone fractures or treatment of children with stents who cannot get permanent implants due to their non-terminated growth.When using magnesium based alloys as biodegradable implant material, one challenge is the local control of the dissolution behaviour (corrosion). Many conventional alloys which are prepared by casing techniques show on the one hand a very localized dissolution and on the other hand a dissolution that proceeds with a too high rate which leads to an impairment of the implant's functionality and also might lead to a damage of the surrounding tissue. In the previous project a well-directed dissolution of the material was intended to be achieved by multilayer systems and gradient layers. It was shown that this approach is not feasible. However, it could also be shown that the dissolution of the magnetron deposited alloys was much more homogeneous compared to cast alloys. Due to these reasons the focus of this proposal is the identification of a suitable alloy which on the one hand does not contain any alloying elements that are harmful to the human metabolism and on the other hand shows a suitable dissolution behaviour in the human body while having a sufficient ductility to be implanted without difficulties at the same time. Within the scope of this project the fatigue behaviour of suitable alloys shall be investigated additionally in order to be able to make a statement about the mechanical behaviour in a corroded state.

该提案是计划作为项目的后续工作，磁控溅射镁合金制成的生物可降解薄膜支架的制造。它描述了平面的，独立的，结构化的薄膜的可生物降解的镁基合金制造的磁控溅射和通过溅射方法，以及合适的连接技术的开发，用于生产支架和这些组件的疲劳试验的表征制造和表征。生物可降解材料在植入材料领域中形成了一组越来越重要的材料，其应用于不需要永久植入物或甚至不利的地方，例如用于骨折的固定或由于其非终止生长而无法获得永久植入物的儿童的支架治疗。当使用镁基合金作为生物可降解植入材料时，一个挑战是溶解行为（腐蚀）的局部控制。通过套管技术制备的许多常规合金一方面显示出非常局部的溶解，另一方面显示出以太高的速率进行的溶解，这导致植入物的功能受损，并且还可能导致周围组织的损伤。在之前的项目中，材料的良好定向溶解旨在通过多层系统和梯度层来实现。结果表明，这种做法是不可行的。然而，也可以表明，磁控管沉积合金的溶解比铸造合金均匀得多。由于这些原因，该建议的重点是识别合适的合金，该合金一方面不包含任何对人体代谢有害的合金元素，另一方面在人体中显示出合适的溶解行为，同时具有足够的延展性以同时无困难地植入。在本项目范围内，还应研究适当合金的疲劳性能，以便能够说明腐蚀状态下的机械性能。