Engineering of composite particles to enhance performance in respiratory drug delivery

复合颗粒工程增强呼吸药物输送性能

• 批准号: LP100100451
• 负责人: Prof Daniela Traini
• 金额: $ 23.35万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-04-21 至 2015-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP100100451
• 关键词: Engineering; composite; particles; enhance; performance

Respiratory conditions such as asthma and chronic pulmonary disease affect in excess of 5.8 million Australians and the common method of treatment is via drug inhalation. Although a wide range of drugs are commercially available as dry powder inhalers the efficiency of these systems is poor, with most devices delivering less than 20% to the lung. This project will develop a new method of high-efficiency respiratory drug delivery based on composite particles. The technology developed from this project will advance Australia’s Research & Innovation and Pharmaceutical industry sector, and improve healthcare outcomes in the government’s key priority area of Promoting and maintaining good health: ‘A healthy start to life’ and ‘Ageing well’

哮喘和慢性肺部疾病等呼吸道疾病影响着580多万澳大利亚人，治疗的常见方法是吸入药物。尽管市面上有多种药物可作为干粉吸入器出售，但这些系统的效率很低，大多数设备向肺部输送的药物不到20%。本项目将开发一种基于复合微粒的高效呼吸道给药新方法。通过该项目开发的技术将促进澳大利亚的研究与创新和制药行业，并改善政府促进和保持良好健康的关键优先领域的医疗保健成果，这两个领域是：健康的生活开端和良好的衰老。