One for all and all for one: Engineering a drug delivery platform for DNA vaccines to the lung

一对一、多对一：设计用于肺部 DNA 疫苗的药物输送平台

• 批准号: LP140100181
• 负责人: Prof Daniela Traini
• 金额: $ 34.05万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-05-11 至 2018-05-10
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP140100181
• 关键词: Engineering; drug; delivery; platform; DNA

Vaccination using next generation DNA plasmids is hindered by the lack of a suitable delivery technology. This project aims to develop a low-cost vaccination platform that can deliver any DNA vaccine via inhalation. High efficiency dry powder particles that contain a novel synthetic cell penetration enhancer and incorporate the drug delivery vehicle in a disposable inhalation device will be engineered. The project aims to help develop a fundamental understanding of the properties that govern interactions in these systems, and a number of in vitro tools that can be used by the wider scientific community. Ultimately, a single platform that can be used for the vaccination of any disease will be created.

使用下一代DNA质粒的疫苗接种由于缺乏合适的递送技术而受到阻碍。该项目旨在开发一种低成本的疫苗接种平台，可以通过吸入提供任何DNA疫苗。将设计含有新型合成细胞渗透促进剂并将药物递送载体并入一次性吸入装置中的高效干粉颗粒。该项目旨在帮助发展对这些系统中控制相互作用的特性的基本理解，以及一些可供更广泛的科学界使用的体外工具。最终，将创建一个可用于任何疾病疫苗接种的单一平台。