Smartdrops - Shaping the future of particle technology

Smartdrops - 塑造粒子技术的未来

• 批准号: DP150100865
• 负责人: Prof Daniela Traini
• 金额: $ 35.98万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-16 至 2018-08-15
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150100865
• 关键词: Smartdrops; Shaping; future; particle; technology

The aim of this project is to develop a particle engineering technology, based on microfluidics, that results in micro-droplets with controlled geometry and morphology. These Smartdrops will be used to target respiratory macrophages for the delivery of inflammatory suppressants, since their dimensions can be controlled to optimise lung deposition and macrophage recognition. The project aims to develop an aerosol inhaler and a series of physico-chemical and in vitro characterisation tools that will be used to study Smartdrop formation, aerosol properties and their interactions with cells. The outcome of this project is intended to be the development of a technology for treating chronic lung inflammation which could also be utilised for a number of other commercial applications.

该项目的目的是开发一种基于微流控技术的粒子工程技术，以产生具有可控几何和形态的微滴。这些SmartDrops将被用于靶向呼吸巨噬细胞，以输送炎症抑制药，因为它们的尺寸可以被控制，以优化肺沉积和巨噬细胞识别。该项目旨在开发一种气雾剂吸入器和一系列物理化学和体外表征工具，用于研究SmartDrop的形成、气溶胶特性及其与细胞的相互作用。该项目的成果是开发一种治疗慢性肺部炎症的技术，该技术也可用于其他一些商业应用。