Engineering pressurized liquid droplets to generate high-efficiency aerosols for targeted respiratory delivery

加压定量吸入器（pMDI）用于呼吸系统疾病的许多宏观方面已得到认可，但尚未在基本水平上得到理解并相应地加以利用。特别地，非水性pMDI中的液滴充电机制仍然难以捉摸。目前，虽然市场上有各种各样的药物作为pMDI，但这些系统的效率很差，大多数设备向肺部输送的药物不到20%。 深入了解这些系统对于成功提高工业中气雾剂制剂的性能至关重要，最终转化为上级患者治疗。该项目将创建pMDI制剂的理论模型，可应用于新一代吸入药物的开发。

Many macroscopic aspects of pressurised Metered Dose Inhaler (pMDI) for respiratory diseases are recognised, but are yet to be understood at the basic level and accordingly exploited. In particular, the droplet charge mechanism in non-aqueous pMDIs remains elusive. Currently, although a wide range of drugs are commercially available as pMDIs, the efficiency of these systems is poor, with most devices delivering less than 20 per cent to the lung. An insight into these systems is crucial to successfully enhance the performance of aerosol formulations in industry, ultimately translating into superior patient therapy. This project will create a theoretical model for pMDI formulation that can be applied to the development of a new generation of inhalation medicines.