Role of ubiquitin in retrovirus budding

泛素在逆转录病毒出芽中的作用

• 批准号: 13165873
• 负责人: Professor Dr. Ulrich Schubert
• 金额: --
• 依托单位: Virologisches Institut - Klinische und Molekulare Virologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2008-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/13165873?language=en
• 关键词: Role; ubiquitin; retrovirus; budding

ing virions. The major ephasis on this proposal is focused on the role of Ubiquitin and Ubiquitin modifying enzymes (lyases and hydrolases) in retrovirus budding. With this we will continue our previous studies in this field where we together with others demonstrated, that an upsteam factor of ther Ubiquitin-proteasome system (UPS), the 26S proteasome, is required for efficient budding of HIV-1 and some other retroviruses. Our work will contribute to the basic understanding of virus budding. Further it might also lead to the validation of specific components of UPS as potential targets for novel antiretroviral therapy.

荷兰国际集团(ing)病毒粒子。这一建议的主要重点是集中在泛素和泛素修饰酶（裂解酶和水解酶）在逆转录病毒出芽中的作用。有了这个，我们将继续我们之前在这个领域的研究，我们和其他人一起证明了他们的泛素蛋白酶体系统（UPS）的一个上行因子，26S蛋白酶体，是HIV-1和其他一些逆转录病毒有效出芽所必需的。我们的工作将有助于对病毒出芽的基本认识。此外，它还可能导致UPS的特定成分作为新型抗逆转录病毒治疗的潜在靶点的验证。