CAREER: Molecular Rhenium(V) Oxotransferases

这个无机化学、生物无机化学和金属有机化学项目的职业奖项支持加州大学洛杉矶分校化学系的Mahdi M.Abu-Omar博士在氧转移反应方面的研究和教育。将制备新的Re基催化剂，并将其用于强化亚硫醚的氧转移化学。我们将用光谱和动力学方法详细研究通式为ReOCl3LL‘的络合物的催化反应。模型体系的密度泛函理论计算将被用来理解催化反应活性。利用这些结果，将设计出抗降解的手性Re(V)恶唑啉配合物，以促进不对称氧转移反应。亚砜催化烯烃不对称环氧化反应将开发出高效的新型催化剂。这一职业奖的教育部分将侧重于将当代研究问题纳入无机化学本科课程，并将开发新的问题会议方法。

This CAREER award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research and education on oxygen transfer reactions by Dr. Mahdi M. Abu-Omar of the Chemistry Department, University of California - Los Angeles. New rhenium-based catalysts will be prepared and used to enhance the oxygen-transfer chemistry of sulfoxides. The catalytic reactions of complexes of the general formula ReOCl3LL' will be studied in detail using spectroscopic and kinetic methods. Density Functional Theory calculations on model systems will be used to understand the catalytic reactivities. Using the results, chiral Re(V) oxazoline complexes that are resistant to degradation will be designed in order to promote asymmetric oxo-transfer reactions. Efficient new catalysts will be developed for the asymmetric epoxidation of olefins by sulfoxides. The educational component of this CAREER Award will focus on incorporating contemporary research issues into undergraduate classes in inorganic chemistry and new approaches to problem sessions will be developed.