CAREER: Molecular Rhenium(V) Oxotransferases

职业：分子铼(V) 氧化转移酶

• 批准号: 9874857
• 负责人: Mahdi Abu-Omar
• 金额: $ 33.15万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-15 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9874857&HistoricalAwards=false
• 关键词: CAREER; Molecular; Rhenium; Oxotransferases

This CAREER award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research and education on oxygen transfer reactions by Dr. Mahdi M. Abu-Omar of the Chemistry Department, University of California - Los Angeles. New rhenium-based catalysts will be prepared and used to enhance the oxygen-transfer chemistry of sulfoxides. The catalytic reactions of complexes of the general formula ReOCl3LL' will be studied in detail using spectroscopic and kinetic methods. Density Functional Theory calculations on model systems will be used to understand the catalytic reactivities. Using the results, chiral Re(V) oxazoline complexes that are resistant to degradation will be designed in order to promote asymmetric oxo-transfer reactions. Efficient new catalysts will be developed for the asymmetric epoxidation of olefins by sulfoxides. The educational component of this CAREER Award will focus on incorporating contemporary research issues into undergraduate classes in inorganic chemistry and new approaches to problem sessions will be developed.

这个职业奖在无机，生物无机和有机化学计划支持研究和教育的氧转移反应博士。加州-洛杉矶大学化学系的阿布-奥马尔说。 将制备新的铱基催化剂并用于增强亚砜的氧转移化学。 本文将用光谱和动力学方法详细研究通式为ReOCl_3LL '的配合物的催化反应。 模型系统的密度泛函理论计算将用于理解催化反应性。 使用的结果，手性Re（V）恶唑啉配合物，是耐降解将被设计，以促进不对称氧代转移反应。 因此，亚砜不对称环氧化烯烃的研究将成为开发新型高效催化剂的重要方向。 该职业奖的教育部分将侧重于将当代研究问题纳入无机化学本科课程，并将开发新的解决问题的方法。