CAREER: Design and Synthesis of Polypeptide Block Copolymers for the Construction of Novel, Self-Assembling Nanostructures

职业：设计和合成多肽嵌段共聚物，用于构建新型自组装纳米结构

• 批准号: 9875776
• 负责人: Vincent Conticello
• 金额: $ 39.8万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9875776&HistoricalAwards=false
• 关键词: CAREER; Design; Synthesis; Polypeptide; Block

This CAREER award to Dr. Vincent P. Conticello at Emory University is supported by the Advanced Materials Program in the Chemistry Division. The focus of the research is the design, biosynthesis and characterization of polypeptide block copolymers that are capable of self-assembly into well-defined nanostructures. Initial targets will be based on the structural model of spider dragline silk, which is organized into distinct rigid and flexible domains, accounting for its unusual combination of high compressive and tensile strength. Specific elements of the research will be design and evaluation of spider silk analogs using molecular modeling techniques, biosynthesis of candidate proteins using recombinant DNA techniques, and characterization of the structure and self-assembly of the synthetic block co-polypeptides in both solution and the solid state. By using the principles of protein structure and concepts of polymer materials science, non-natural protein-based materials will be prepared with properties that emulate or exceed natural materials.The teaching component of the CAREER award will parallel the establishment of a new Department of Physical, Materials and Computational Science. Core curricula based on interdisciplinary graduate courses in Biotechnology and Chemistry and Chemistry of Materials will be developed. Included will be advisor/advisee programs for new students, development of a web-based undergraduate inorganic chemistry course, and establishment of Freshmen seminars in Materials Chemistry.

这个职业奖给埃默里大学的Vincent P. Conticello博士，由化学系的先进材料项目支持。研究的重点是多肽嵌段共聚物的设计，生物合成和表征，这些共聚物能够自组装成定义良好的纳米结构。 最初的目标将基于蜘蛛拖丝的结构模型，该结构模型被组织成不同的刚性和柔性域，这是由于其具有高抗压强度和抗拉强度的不寻常组合。该研究的具体内容将是使用分子建模技术设计和评估蜘蛛丝类似物，使用重组DNA技术生物合成候选蛋白质，以及表征溶液和固态合成块共多肽的结构和自组装。通过使用蛋白质结构的原理和高分子材料科学的概念，非天然蛋白质基材料将被制备成具有模仿或超过天然材料的性能。CAREER奖的教学部分将与物理，材料和计算科学的新部门的建立平行。 将开发基于生物技术、化学和材料化学的跨学科研究生课程的核心课程。包括将为新生提供顾问/顾问计划，开发基于网络的本科无机化学课程，并建立材料化学新生研讨会。