Protein Mimetics Based on Beta Amino Acids
基于 β 氨基酸的蛋白质模拟物
基本信息
- 批准号:9905566
- 负责人:
- 金额:$ 48.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-07-01 至 2002-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The foci of this research are threefold. First, methods will be devised for the practical, asymmetric synthesis of beta-amino acids. Second, the thermodynamics of L+2 helix formation in aqueous solution will be determined. Third, beta-peptides that fold into well-defined tertiary and quaternary structures in aqueous solution will be constructed. These studies will represent a significant step towards design of a variety of advanced polymers with predetermined shapes and functional properties. With this Grant Opportunities for Academic Liaison with Industry (GOALI) award, the Organic and Macromolecular Chemistry Program and the Office of Multidisciplinary Activities of the Mathematics and Physical Sciences Directorate are supporting the research of Dr. William F. DeGrado of the Department of Biochemistry and Biophysics at the University of Pennsylvania and Dr. Mark A. Scialdone of the Biochemical Sciences and Engineering DuPont Life Sciences Enterprise. The goal of the research is to design and study non-biological polymers that fold into unique three-dimensional structures. Specifically, chains of beta-amino acids will be designed that fold, in water, to give not only predetermined secondary structures, but also tertiary and quaternary structures. The work has broad implications for the preparation of new materials of interest to materials science and to the pharmaceutical industry. Further, the research provides an exciting training opportunity for postdoctoral researchers since the participants will gain both academic and industrial experience.
这项研究的重点有三个方面。首先,将设计用于β-氨基酸的实用的不对称合成的方法。 第二,确定了水溶液中L+2螺旋形成的热力学。 第三,将构建在水溶液中折叠成明确的三级和四级结构的β-肽。 这些研究将代表设计具有预定形状和功能特性的各种先进聚合物的重要一步。有了这个赠款机会学术联络与工业(GOALI)奖,有机和高分子化学计划和数学和物理科学理事会的多学科活动办公室正在支持威廉·F博士的研究。宾夕法尼亚大学生物化学和生物物理系的DeGrado博士和MarkA。杜邦生命科学企业生化科学与工程公司的Scialdone。 该研究的目标是设计和研究折叠成独特三维结构的非生物聚合物。具体地,β-氨基酸链将被设计为在水中折叠,以不仅给出预定的二级结构,而且给出三级和四级结构。 这项工作对材料科学和制药工业感兴趣的新材料的制备具有广泛的影响。 此外,该研究为博士后研究人员提供了一个令人兴奋的培训机会,因为参与者将获得学术和工业经验。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
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William DeGrado其他文献
The delicate balance between apolar packing and hydrogen bonding determines membrane protein assembly and function
- DOI:
10.1016/j.bpj.2021.11.585 - 发表时间:
2022-02-11 - 期刊:
- 影响因子:
- 作者:
Huong T. Kratochvil;William DeGrado - 通讯作者:
William DeGrado
Computational Design of Transmembrane Peptides that Bind and Inhibit the Erythropoietin Receptor
- DOI:
10.1016/j.bpj.2019.11.2069 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Marco Mravic;William DeGrado - 通讯作者:
William DeGrado
Towards the <em>de novo</em> Design of Functional Metalloproteins
- DOI:
10.1016/j.bpj.2019.11.2670 - 发表时间:
2020-02-07 - 期刊:
- 影响因子:
- 作者:
Ketaki Belsare;Nicholas Polizzi;Lior Shtayer;William DeGrado - 通讯作者:
William DeGrado
Mapping Water Density to Design New Blockers Against a Viral Proton Channel
- DOI:
10.1016/j.bpj.2011.11.3708 - 发表时间:
2012-01-31 - 期刊:
- 影响因子:
- 作者:
Giacomo Fiorin;Vincenzo Carnevale;Jun Wang;Chunlong Ma;Tuo Wang;Fanghao Hu;Robert Lamb;Lawrence Pinto;Mei Hong;William DeGrado;Michael Klein - 通讯作者:
Michael Klein
Monitoring Proton Flux Quantitatively; Influenza Proton Channel A/M2
- DOI:
10.1016/j.bpj.2009.12.1212 - 发表时间:
2010-01-01 - 期刊:
- 影响因子:
- 作者:
Thom Leiding;Alexei Polishchuk;William DeGrado;Cecilia Hägerhäll;Sergei Vinogradov;Sindra Peterson Årsköld - 通讯作者:
Sindra Peterson Årsköld
William DeGrado的其他文献
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{{ truncateString('William DeGrado', 18)}}的其他基金
NSF/MCB-BSF: De novo design of minimalistic light-switchable protein binding domains
NSF/MCB-BSF:简约光可切换蛋白结合域的从头设计
- 批准号:
2306190 - 财政年份:2023
- 资助金额:
$ 48.8万 - 项目类别:
Standard Grant
Collaborative Research: De Novo Protein Constructs for Photosynthetic Energy Transduction
合作研究:用于光合能量转导的从头蛋白质构建体
- 批准号:
2108660 - 财政年份:2021
- 资助金额:
$ 48.8万 - 项目类别:
Continuing Grant
Collaborative Research: De novo Protein Constructs for Photosynthetic Energy Transduction
合作研究:用于光合能量转导的从头蛋白质构建体
- 批准号:
1709506 - 财政年份:2017
- 资助金额:
$ 48.8万 - 项目类别:
Continuing Grant
Collaborative Research: De novo Protein Constructs for Photosynthetic Energy Transduction
合作研究:用于光合能量转导的从头蛋白质构建体
- 批准号:
1413295 - 财政年份:2014
- 资助金额:
$ 48.8万 - 项目类别:
Standard Grant
Libraries of Template-Constrained Cyclic Peptides
模板限制的环肽文库
- 批准号:
9634646 - 财政年份:1996
- 资助金额:
$ 48.8万 - 项目类别:
Standard Grant
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