New analgesics based on µ-conotoxins: structure-based design of helical mimetics

基于μ-芋螺毒素的新型镇痛药：基于结构的螺旋模拟物设计

• 批准号: DP1094212
• 负责人: Prof Raymond Norton
• 金额: $ 24.39万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094212
• 关键词: New; analgesics; based; conotoxins; structure

Diseases in which voltage-gated sodium channels are implicated are contributors to morbidity and mortality in the Australian population, and this project promises to provide new leads for the future development of drugs to treat such diseases, in particular analgesics for the treatment of chronic pain. The generation of these leads will entail the development of new approaches to mimicking key regions of peptides and proteins in drug-like molecules. This is a highly interdisciplinary project, spanning structural biology, molecular design, medicinal chemistry, molecular biology and electrophysiology, and the training of PhD graduates with such broad experience represents another national benefit of the project.

涉及电压门控钠通道的疾病是导致澳大利亚人口发病率和死亡率的因素，该项目有望为未来治疗此类疾病的药物，特别是治疗慢性疼痛的止痛药的开发提供新的线索。这些先导化合物的产生将需要开发新的方法来模拟类药物分子中的多肽和蛋白质的关键区域。这是一个高度跨学科的项目，横跨结构生物学、分子设计、药物化学、分子生物学和电生理学，培养具有如此广泛经验的博士毕业生是该项目的另一个国家利益。