National High Field FT-ICR Mass Spectroscopy Facility

国家高场 FT-ICR 质谱装置

• 批准号: 9909502
• 负责人: Alan Marshall
• 金额: $ 576.06万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9909502&HistoricalAwards=false
• 关键词: National; Field; FT; ICR; Mass

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, Alan G. Marshal, Christopher L. Hendrickson and Mark R. Emmett of Florida State University (FSU) and John R. Eyler of the University of Florida will continue to operate the Fourier-Transform Ion Cyclotron Resonance/Mass Spectrometry (FT-ICR/MS) Facility, housed in the National High Magnetic Field Laboratory (NHMFL) at FSU. Studies to be carried out using the FT-ICR/MS facility during the next grant period include isotopic resolution of proteins; highly accurate mass spectra of complex mixtures such as petroleum feedstocks; analysis of environmental mixtures (oil spills; bioremediation); and studies exploring the use of magnetic fields to control ion/molecule reactions. Design and development efforts will focus on the installation of a matrix-assisted laser desorption/ionization (MALDI) FT-ICR/MS instrument into an 11 tesla magnet; installation of an electrospray ionization (ESI) FT-ICR/MS instrument using a 17 tesla magnet; and the development of mass-selective external ion accumulation, which should lead to improvements in sensitivity and dynamic range. The PIs also plan further development of optical spectroscopy of mass-selected gas phase molecular ions using FT-ICR. They will continue to provide access and services to the external user community, including provision of funds for visiting graduate students and postdocs; and mass analysis for non-FT-ICR MS experts and industrial concerns. Education and outreach efforts will continue, such as regular publication of newsletters, organization of biennial conferences, and participation of undergraduates in summer research programs. The Fourier Transform-Ion Cyclotron Resonance/Mass Spectrometry Facility at Florida State University is a unique national resource that provides state-of-the-art analytical instrumentation and mass spectral analysis to chemists and biochemists in US academic and industrial institutions. Studies that are carried out at the facility lead to a better understanding of the behavior of biomolecules, and the structure of biomolecules, complex mixtures important in environmental chemistry, and petroleum products. This facility also makes an important contribution to the training and education of significant numbers of graduate students and postdoctoral fellows in the use of advanced mass spectrometry.

在化学研究仪器和设施（CRIF）项目的支持下，佛罗里达州立大学（FSU）的Alan G. Marshal、Christopher L. Hendrickson和Mark R. Emmett以及佛罗里达大学的John R. Eyler将继续操作傅里叶变换离子回旋共振/质谱（FT-ICR/MS）设备，该设备位于佛罗里达州立大学的国家高磁场实验室（NHMFL）。下一个资助期将使用FT-ICR/MS设备进行的研究包括蛋白质的同位素解析；高精度的复杂混合物质谱，如石油原料；环境混合物分析（溢油；生物修复）；以及探索利用磁场控制离子/分子反应的研究。设计和开发工作将侧重于将基质辅助激光解吸/电离（MALDI） FT-ICR/MS仪器安装到11特斯拉磁铁中；使用17特斯拉磁铁安装电喷雾电离（ESI） FT-ICR/MS仪器；质量选择性外离子积累的发展，将导致灵敏度和动态范围的提高。pi还计划使用FT-ICR进一步开发大量选择气相分子离子的光谱学。他们将继续为外部用户社区提供访问和服务，包括为访问研究生和博士后提供资金；为非ft - icr质谱专家和工业界提供大量分析。教育和推广工作将继续进行，例如定期出版通讯，组织两年一次的会议，以及让本科生参加夏季研究项目。佛罗里达州立大学的傅里叶变换-离子回旋共振/质谱分析设施是一个独特的国家资源，为美国学术和工业机构的化学家和生物化学家提供最先进的分析仪器和质谱分析。在该设施进行的研究使人们更好地了解生物分子的行为、生物分子的结构、环境化学中重要的复杂混合物和石油产品。该设施还为培训和教育大量使用先进质谱法的研究生和博士后做出了重要贡献。