FT/ICR/MS:Technique Development and Non-Biological Applications

这个项目是在一般地区的分析和表面 化学和质谱分析的子领域。 主 这项实验计划的主旨是开发一种 傅里叶变换质谱仪（FTMS）， 质量分辨率和质量精度测量可以在 显著提高信噪比。 中心这些 仪器的改进是磁场的减少 静态不均匀性在7特斯拉超导螺线管， 由非磁性材料构造所述捕获离子单元，以及 采用新的细胞几何形状，探索自然， 限制FTMS仪器中的噪声，并增强 分析信号相对于此噪声通过使用新的 激发和检测技术。 进一步改进金融交易管理系统 灵敏度，特别是对于难以分离的样品， 预计使用新开发的快速中性束离子 源头 将改进后的仪器应用于各种分析和 机械问题应该引起新的见解， 团簇的化学和物理， 聚合物，在气相离子分子化学，并在 电极表面成分的表征。 此外，本发明还 从这项研究中得到的改进的FTMS技术可以 预计将对生物科学产生广泛而积极的影响。

This project is in the general area of analytical and surface chemistry and in the subfield of mass spectrometry. The primary thrust of this experimental program is the development of a Fourier transform mass spectrometer (FTMS) with which ultrahigh mass resolution and mass accuracy measurements can be made at significantly improved signal-to-noise ratios. Central to these instrumentation improvements is the reduction of magnetic field static inhomogeneity in the 7 Tesla superconducting solenoid by constructing the trapped-ion cell from non-magnetic materials and employing new cell geometries, exploration of the nature and limits to noise in the FTMS instrument, and enhancement of the analytical signal relative to this noise through use of new excitation and detection techniques. Further improvements in FTMS sensitivity, especially for difficult-to-ionize samples, can be expected with the use of a newly developed fast neutral beam ion source. Applications of this improved instrument to various analytical and mechanistic problems should give rise to new insights in the chemistry and physics of clusters, in the characterization of polymers, in gas phase ion-molecule chemistry, and in the characterization of electrode surface constituents. Additionally, the improved FTMS technology that derives from this research can be expected to impact broadly and positively in the biosciences.