Development of a 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer

21特斯拉傅里叶变换离子回旋共振质谱仪的研制

• 批准号: 0938158
• 负责人: Alan Marshall
• 金额: --
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0938158&HistoricalAwards=false
• 关键词: Development; 21; Tesla; Fourier; Transform

DMR-0938158PIs: Boebinger, MarshallThis award will fund the design, construction, and optimization of performance of a 21 Tesla ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometer(FTICR-MS). The rationale for this project draws from the workshop, "Science Challenges and Design Concepts for the Next-Generation High-Performance FT-ICR Mass Spectrometer," organized jointly by National High Magnetic Field Laboratory (NHMFL) and the Environmental Molecular Scienes Laboratory (EMSL), and held on 16-17 January, 2008 at NHMFL. Feasibility of the magnet design has been demonstrated by NHMFL's Magnet Science and Technology group, and three vendors have offered to build it. The other components of the spectrometer will be designed and built by NHMFL permanent staff and two postdoctoral researchers. Ion optics design will be guided by large-scale supercomputer simulations (modeling the interaction of more than 1,000,000 ions). This project will improve every aspect of technical performance: sample introduction, ion source(s), ion transmission, ion external accumulation, ion cyclotron resonance (ICR) excitation and detection, computerized and automated instrument control, higher magnetic field, and data reduction. Magnet delivery will take three years, allowing for extensive progress in design of the rest of the instrument in the interim. Applications will focus on petroleomics, top-down proteomics, and hydrogen/deuterium exchange to map contact surfaces in biomacromolecular complexes.

DMR-0938158 PI：Boebinger，Marshall该奖项将资助21特斯拉超高分辨率傅里叶变换离子回旋共振质谱仪（FTICR-MS）的设计、建造和性能优化。该项目的基本原理来自于2008年1月16日至17日在国家高磁场实验室（NHMFL）和环境分子科学实验室（EMSL）联合组织的研讨会，“下一代高性能FT-ICR质谱仪的科学挑战和设计概念”。磁体设计的可行性已经由NHMFL的磁体科学和技术小组进行了论证，三家供应商已经提出建造它。光谱仪的其他组件将由NHMFL的永久工作人员和两名博士后研究人员设计和建造。离子光学设计将由大型超级计算机模拟（模拟超过1，000，000个离子的相互作用）指导。该项目将改进技术性能的各个方面：样品引入、离子源、离子传输、离子外部积累、离子回旋共振（ICR）激发和检测、计算机化和自动化仪器控制、更高的磁场和数据简化。磁铁的交付将需要三年时间，在此期间，仪器其余部分的设计将取得广泛进展。应用将集中在石油组学，自上而下的蛋白质组学和氢/氘交换，以映射生物大分子复合物的接触表面。