Gene and Development Investigated in the Biology Curriculum

生物课程中的基因与发育研究

• 批准号: 9950647
• 负责人: Michael Campbell
• 金额: $ 5.72万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9950647&HistoricalAwards=false
• 关键词: Gene; Development; Investigated; Biology; Curriculum

Students majoring in biology usually get a good foundation in genetics and biochemistry but many fail to grasp the concept that many genes encode for protein products that regulate and are regulated by developmental events. To address this deficiency we will integrate a number of courses within the biology curriculum that will result in a research based system that win teach a genetic approach to developmental biology. This system will rely on the use of zebra fish as a model animal system and potato as a model plant system. Student's investigators will isolate and characterize genes from these organisms and these genes will then be used to develop undergraduate exercises that will examine the association of gene expression with different stages of development. Initial gene isolation experiments will be conducted in an undergraduate molecular biology course. The genes isolated will be both random clones and genes targeted to specific metabolic enzymes. These genes will then be used by students in animal and plant developmental biology courses as pedagogical tools for demonstrating the interaction of genes and development. Additional courses in biochemistry, protein structure and function, and histology will give students the opportunity to examine different aspects of the genes and gene products isolated. With this approach we intend to instill in undergraduate biology majors a sense of the scientific process by giving them ownership and input into the experimental process.

生物学专业的学生通常在遗传学和生物化学方面有良好的基础，但许多人未能掌握这样的概念：许多基因编码调节发育事件并受发育事件调节的蛋白质产物。为了解决这一缺陷，我们将在生物学课程中整合一些课程，这将形成一个基于研究的系统，该系统将教授发育生物学的遗传方法。该系统将依赖于使用斑马鱼作为模型动物系统和马铃薯作为模型植物系统。学生的研究人员将从这些生物体中分离和表征基因，然后将这些基因用于开发本科练习，以检查基因表达与不同发育阶段的关联。初始基因分离实验将在本科生分子生物学课程中进行。分离的基因将是随机克隆和针对特定代谢酶的基因。然后，学生将在动物和植物发育生物学课程中使用这些基因作为展示基因与发育相互作用的教学工具。生物化学、蛋白质结构和功能以及组织学的附加课程将使学生有机会检查分离的基因和基因产物的不同方面。通过这种方法，我们打算通过赋予生物学专业本科生对实验过程的所有权和投入，向他们灌输对科学过程的认识。