MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for Research and Research Training at Barnard College

该奖项由主要研究仪器和化学研究仪器项目支持。巴纳德学院的Michael Campbell教授及其同事Christian Rojas， Dina Merrer和Marisa Buzzeo获得了一台400 MHz核磁共振光谱仪，配备了自动采样器和低温功能。该光谱仪允许在各种领域的研究，如那些加速具有重要经济意义的化学反应，以及允许研究生物相关物种。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。该仪器对该机构的女学生产生了积极影响，她们接受了研究方面的培训，然后在其他机构攻读博士学位。授予这台400兆赫光谱仪的目的是加强各级的研究和教育。它尤其影响了能够表现出协同相互作用的过渡金属基分子的合成和金属催化的氨基糖基化反应的发展，以制备立体变化的2-氨基糖。该光谱仪有助于理解非统计动力学对碳-碳- π键应变反应的影响，并有助于开展含硒生物分子的电化学研究。该仪器还为研究人员开发绿色化学催化剂和研究金属酶介导的烷烃转化机制提供服务。光谱仪有利于研究抑制细胞骨架调节蛋白形成的小分子。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Michael Campbell from Barnard College and colleagues Christian Rojas, Dina Merrer and Marisa Buzzeo have acquired a 400 MHz NMR spectrometer equipped with an automatic sampler and low-temperature capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts female students at this institution, who are trained in research and then go on to PhD programs at other institutions.The award of this 400 MHz spectrometer is aimed at enhancing research and education at all levels. It especially impacts studies on the syntheses of transition metal-based molecules capable of exhibiting cooperative interactions and in the development of metal-catalyzed amidoglycosylation reactions to prepare stereo-varied 2-amino sugars. The spectrometer is helpful in understanding the influence of nonstatistical dynamics on reactions of carbenes with strained carbon-carbon pi bonds and in carrying out electrochemical studies of selenium-containing biological molecules. The instrument also serves researchers developing catalysts for green chemistry and investigating mechanisms of metalloenzyme-mediated alkane transformations. The spectrometer benefits studies of small-molecules that inhibit the cytoskeletal regulatory proteins formins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.