MRI: Acquisition of a 400 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for Research and Research Training at Barnard College

MRI：巴纳德学院采购 400 MHz 核磁共振 (NMR) 波谱仪用于研究和研究培训

• 批准号: 1827936
• 负责人: Michael Campbell
• 金额: $ 39.9万
• 依托单位: Barnard College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1827936&HistoricalAwards=false
• 关键词: MRI; Acquisition; 400; MHz; Nuclear

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. Professor Michael Campbell from Barnard College and colleagues Christian Rojas, Dina Merrer and Marisa Buzzeo have acquired a 400 MHz NMR spectrometer equipped with an automatic sampler and low-temperature capabilities. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The instrument positively impacts female students at this institution, who are trained in research and then go on to PhD programs at other institutions.The award of this 400 MHz spectrometer is aimed at enhancing research and education at all levels. It especially impacts studies on the syntheses of transition metal-based molecules capable of exhibiting cooperative interactions and in the development of metal-catalyzed amidoglycosylation reactions to prepare stereo-varied 2-amino sugars. The spectrometer is helpful in understanding the influence of nonstatistical dynamics on reactions of carbenes with strained carbon-carbon pi bonds and in carrying out electrochemical studies of selenium-containing biological molecules. The instrument also serves researchers developing catalysts for green chemistry and investigating mechanisms of metalloenzyme-mediated alkane transformations. The spectrometer benefits studies of small-molecules that inhibit the cytoskeletal regulatory proteins formins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。 来自巴纳德学院的Michael坎贝尔教授及其同事Christian Rojas、Dina Merrer和Marisa Buzzeo获得了一台配备自动采样器和低温功能的400 MHz NMR光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及研究生物相关物种。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器对该机构的女学生产生了积极影响，她们接受了研究培训，然后在其他机构攻读博士学位。授予这台400 MHz频谱仪的目的是加强各级的研究和教育。它特别影响了能够表现出合作相互作用的过渡金属基分子的合成研究，以及金属催化的酰胺基糖基化反应的发展，以制备立体变化的2-氨基糖。该光谱仪有助于理解非统计动力学对具有应变碳-碳π键的卡宾反应的影响，并有助于对含硒生物分子进行电化学研究。该仪器还为研究人员开发绿色化学催化剂和研究金属酶介导的烷烃转化机制提供服务。该光谱仪有利于抑制细胞骨架调节蛋白formins的小分子研究。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Silver(II) and Silver(III) Intermediates in Alkene Aziridination with a Dinuclear Silver(I) Nitrene Transfer Catalyst

• DOI: 10.1021/acscatal.0c00065
• 发表时间: 2020-04-17
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Elkoush, Tasneem;Mak, Choi L.;Campbell, Michael G.
• 通讯作者: Campbell, Michael G.

Visible Light Absorption and Long-Lived Excited States in Dinuclear Silver(I) Complexes with Redox-Active Ligands

具有氧化还原活性配体的双核银 (I) 配合物的可见光吸收和长寿命激发态

• DOI: 10.1021/acs.inorgchem.0c02938
• 发表时间: 2020
• 期刊: Inorganic Chemistry
• 影响因子: 4.6
• 作者: Shields, Dylan J.;Elkoush, Tasneem;Miura-Stempel, Emily;Mak, Choi L.;Niu, Guang-Hao;Gudmundsdottir, Anna D.;Campbell, Michael G.
• 通讯作者: Campbell, Michael G.