SBIR Phase I: Ferroelectric Scaffolds for Peripheral Nerve Regeneration

SBIR 第一阶段：用于周围神经再生的铁电支架

• 批准号: 9960250
• 负责人: Debra Trantolo
• 金额: $ 10万
• 依托单位: Cambridge Scientific Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9960250&HistoricalAwards=false
• 关键词: SBIR; Phase; Ferroelectric; Scaffolds; Peripheral

This Small Business Innovation Research Phase I project is designed to utilize the ferroelectric (FE) properties of alpha helical polypeptides for development of materials for use in tissue repair, especially nerve fiber outgrowths in vitro and in vivo. Esters of poly-L-glutamic acids (PRLG's) are known to display piezoelectric (PE) properties when aligned in magnetic or electric fields. The molecular conformation of the aligned dipoles suggested that the direction of the dipole vector in aligned films may be reversed by application of an electric field, thus giving rise to FE properties. Given our discovery of the FE behavior of poly-methyl-L-glutamic acid, this Phase I project will focus on establishing the feasibility of this biocompatible material to enhance tissue repair in vivo for potential clinical application to peripheral nerve regeneration. Ferroelectrics find a number of applications: pyroelectric detectors, ultrasonic and electroacoustic transducers, and ultrasonic light modulators. The ease with which PRLG can be ordered in an externally applied electric field to create a film with strong dipole alignment suggests that it and other self-organizing and alignable biopolymers may also be suitable materials for development of FE materials for tissue regeneration.

这个小企业创新研究第一阶段项目旨在利用α螺旋多肽的铁电特性来开发用于组织修复的材料，特别是体外和体内的神经纤维生长。已知聚l -谷氨酸酯（PRLG's）在磁场或电场中排列时显示压电（PE）性质。排列偶极子的分子构象表明，在电场的作用下，偶极子矢量在排列膜中的方向可能被逆转，从而产生FE性质。鉴于我们发现了聚甲基- l-谷氨酸的FE行为，本一期项目将重点研究这种生物相容性材料在体内增强组织修复的可行性，并将其应用于周围神经再生的潜在临床应用。铁电体有许多应用：热释电探测器，超声波和电声换能器，超声波光调制器。PRLG可以轻松地在外部施加的电场中有序地形成具有强偶极子排列的薄膜，这表明它和其他自组织和可排列的生物聚合物也可能是开发用于组织再生的FE材料的合适材料。