POWRE: Signal Processing of Spontaneous Arrhythmias Acquired Chronically in an Adriamycin Model of Heart Failure

在美国，每年有200,000人死于心力衰竭。这些死亡中有30%-50%是突然的，并被归因于心脏电异常。心电图学是研究心脏电特性的学科，在预测和预防心脏性猝死方面发挥着重要作用。虽然已经进行了很多研究试图预测心源性猝死，但还没有长期的研究追踪从正常到疾病状态的心电进展。此外，为了建立心源性猝死的短期电生理学预测指标，对自发事件发生前几周、几天和几小时的心电图分析工作还很少。如果可以预测到猝死事件，可以尝试进行长期和短期干预以防止这一事件发生。这项建议的总体目标是开发和使用阿霉素心力衰竭兔模型来研究从正常到猝死事件的心电进展。动物将被配备一个长期植入的心电系统。通过射频遥测，将在动物的整个生命周期内连续记录心电。经典的心电特征以及创新的特征将由计算机计算，并在动物的整个生命周期内进行监测，其中将特别注意事件发生前的变化。这项工作的主要目标将是开发一种短期预测方案，该方案可以预测即将发生的事件，以便在临床环境中可以进行预防/干预，如电疗。

9973513SchuckersOne to two million adults are affected in the United States by heart failure with 200,000 deaths annually. 30-50% of these deaths are sudden and have been attributed to cardiac electrical abnormalities. Electrocardiology, the study of electrical characteristics of the heart, plays a major role in prediction and prevention of sudden cardiac death. Although much research has been performed to attempt to predict sudden cardiac death, no long-term studies have tracked the electrocardiographic progression from normal to diseased state. Furthermore, little work has been done to analyze the electrocardiogram (ECG) in the weeks, days, and hours before a spontaneous event in order to establish a short-term electrophysiologic predictor of sudden cardiac death. If a sudden death episode could be predicted, long- and short-term interventions could be attempted to prevent the event. The overall goal of this proposal is to develop and use an adriamycin rabbit model of heart failure to study the electrocardiographic progression from normal to a sudden death event. Animals will be outfitted with a long-term implanted ECG system. ECGs will be recorded continuously for the lifetime of the animal through radiofrequency-telemetry. Classical ECG features as well as innovative features will be calculated by computer and monitored over the lifetime of the animal where particular attention will be paid to changes preceding an event. The main goal of this work will be the development of a short-term prediction scheme which could predict an impending event such that in the clinical setting preventions/interventions, like electrical therapies may be performed.