Computational Algorithms for Multidimensional Biological Image Organization

多维生物图像组织的计算算法

• 批准号: 9983114
• 负责人: John White
• 金额: $ 89.57万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9983114&HistoricalAwards=false
• 关键词: Computational; Algorithms; Multidimensional; Biological; Image

The microscope has been a widely used tool of biological research for over two hundred years, but interest and developments in microscopy have waxed and waned over the years. Extraordinary advances in genomics over the past few years, however, which have helped identify more physical components of cells and organisms thus creating a new challenge in determining how these parts function together as a living ensemble, have fueled a new demand for microscopy. This project develops an integrated software suite that is used to capture, archive, visualize, analyze and distribute multifocal plane, time-lapse (4-D) microscopic recordings of embryonic development. Advanced visualization aids including roaming space and time, 3-D rendering and arbitrary plane slicing facilitates perception of complex structural dynamics. A comprehensive annotation system enables extensively labeled canonical developmental sequences to be established in a database thereby providing a powerful educational resource for students of embryology.Web site: http://www.loci.wisc.edu/cambio

超过两百年来，显微镜已成为一种广泛使用的生物学研究工具，但是多年来，显微镜的兴趣和发展却逐渐减弱。 然而，在过去的几年中，基因组学的非凡进步有助于确定更多的细胞和生物的物理成分，从而在确定这些部分如何将这些部分作为生活集成在一起的过程中引发了新的挑战，从而促进了对显微镜的新需求。 该项目开发了一个集成的软件套件，用于捕获，存档，可视化，分析和分发多焦点平面，延迟（4-D）胚胎开发的微观记录。 高级可视化辅助设备，包括漫游空间和时间，3-D渲染和任意平面切片，有助于对复杂的结构动力学的感知。 一个综合的注释系统使能够在数据库中建立广泛标记的规范发育序列，从而为胚胎学学生提供强大的教育资源。Web网站：http：//www.loci.wisc..wisc.edu/cambio