CAREER: Microdialysis Sampling Techniques to Assess and Improve Quantitative Sensocompatibility

职业：微透析采样技术评估和提高定量传感相容性

• 批准号: 9984150
• 负责人: Julie Stenken
• 金额: $ 30.05万
• 依托单位: Rensselaer Polytechnic Institute
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2004-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9984150&HistoricalAwards=false
• 关键词: CAREER; Microdialysis; Sampling; Techniques; Assess

This CAREER research program conducted by Dr. Julie Stenken of Rensselaer Polytechnic Institute is supported by the Analytical and Surface Program in the Chemistry Division. The focus of this research is to develop microdialysis probes for in vitro macrophage cell cultures with the goal of monitoring real-time chemical concentrations. The chemicals to be monitored include hydroxyl radical, nitric oxide and prostaglandins. She will evaluate the biocompatibility of a variety of sensor membrane materials. She also will expand her previous work on a cyclodextrin complexation method for concentrating trace chemicals in the cell culture with sampling by microdialysis. The educational component of her research includes the incorporation of this research into her graduate program. Dr. Stenken also plans to develop an outreach educational program for local high schools, directed specifically to underrepresented women and minority students.The impact of this research on the biomedical engineering community is expected to be high. There are a number of complex issues related to the routine use of microdialysis sampling which Dr. Stenken will address. Studying membrane materials and the inflammatory response which they cause will lead to a clearer fundamental understanding of the compatibility of materials with blood and tissues.

由伦斯勒理工学院的Julie Stenken博士进行的这项职业研究计划得到了化学部分析和表面计划的支持。 本研究的重点是开发用于体外巨噬细胞培养的微透析探针，其目标是实时监测化学浓度。 监测的化学物质包括羟自由基、一氧化氮和甘草素。 她将评估各种传感器膜材料的生物相容性。 她还将扩展她之前在环糊精络合方法方面的工作，该方法通过微透析采样来浓缩细胞培养物中的微量化学物质。 她的研究的教育组成部分包括将这项研究纳入她的研究生课程。 Stenken博士还计划为当地高中制定一项外展教育计划，专门针对代表性不足的妇女和少数民族学生。这项研究对生物医学工程界的影响预计将很大。 有一些复杂的问题与常规使用的微透析采样博士。 研究膜材料及其引起的炎症反应将有助于更清楚地了解材料与血液和组织的相容性。