Development of non-blood sampling blood glucose monitoring system based on intravascular microdialysis sampling method

我们尝试开发基于血管内微透析采样法的非采血血糖监测系统。首先，研制了透析液中葡萄糖浓度的连续监测系统。使用该血糖监测系统可连续测定96小时内的血糖浓度。透析液中葡萄糖回收率为48.9%。其次，我们将微透析取样导管插入犬的肘前静脉，测量透析液中的葡萄糖浓度。使用该系统可实现连续3天的血糖监测。血糖浓度与透析液中葡萄糖浓度呈线性关系（r= 0.673）。综上所述，我们开发了基于血管内微透析采样法的非采血血糖监测系统。该系统适用于床边型人工内分泌胰腺连续血糖监测系统。

We are tried to develop non-blood sampling blood glucose monitoring system based on intravascular microdialysis sampling method. Firstly, we fabricated continuous monitoring system of glucose concentration in dialysate. We can measure glucose concentration continuously using this glucose monitoring system during 96 hours. The recovery rate of glucose in dialysate was 48.9%.Secondly, we inserted microdialysis sampling catheter into the antecubital vein of dogs, and measured glucose concentration in the dialysate. Continuous blood glucose monitoring could be achieved during 3 days using this system. There was linear relationship between blood glucose concentration and glucose concentration in the dialysate (r= 0.673)In the conclusion, we have developed non-blood sampling blood glucose monitoring system based on intravascular microdialysis sampling method. This system is suitable for continuous blood glucose monitoring system for bed- side type artificial endocrine pancreas.