CAREER: Well-Defined Low-valent Titanium Reductants

该职业奖在无机、生物无机和有机金属化学项目中支持肯塔基大学化学系Folami Ladipo教授对合成和表征明确的低价钛化合物的研究。本文研究了由杯状[4]芳烃衍生的双（芳酰）配体支持的可溶性Ti（II）和Ti（III）配合物的合成，阐明了它们的结构并测定了它们的氧化还原性质。这些合成子与炔烃、烯烃、亚胺和羰基化合物的反应化学将被研究，并建立了低价钛还原剂的空间和电子性质与它们促进化学和非astero选择性C-C键形成能力之间的相关性。这一知识将导致新的还原剂的发展，这些还原剂在很好理解的机制下运作。本研究的目的是制备和表征新型低氧化态钛配合物，该配合物可作为工业和医学上重要有机化合物合成的选择性还原剂。此外，一些钛试剂本身有望具有有用的催化性能。肯塔基大学将相当重视本科教育，并将对无机课程进行改革。与扬斯敦州立大学建立了一项合作安排，将本科生，特别是妇女和少数民族学生纳入研究生管道。

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research on the synthesis and characterization of well-defined low valent titanium compounds by Professor Folami Ladipo of the Department of Chemistry at the University of Kentucky. The work involves the synthesis of soluble Ti(II) and Ti(III) complexes supported by calix[4]arene-derived bis(aryloxide) ligands, the elucidation of their structure and the determination of their redox properties. The reaction chemistry of these synthons with alkynes, alkenes, imines and carbonyl compounds will be examined, and correlations established between the steric and electronic properties of the low-valent titanium reductants and their ability to promote chemo-and diastero-selective C-C bond formation. This knowledge will lead to the development of new reductants which operate under well-understood mechanisms.The goal of this research is to produce and characterize new complexes of titanium in low oxidation states which can be used as selective reducing agents in the synthesis of industrially and medically important organic compounds. In addition, some of the titanium reagents themselves are expected to possess useful catalytic properties. Considerable emphasis is being placed on undergraduate education, and inorganic course offerings at the University of Kentucky will be revamped. A cooperative arrangement with Youngstown State University has been established which will bring undergraduate students, particularly women and minorities, into the graduate pipeline.