Metals and Hydrogen Bonding

该奖项在无机，生物无机和有机化学计划支持李Brammer，化学系，密苏里大学圣路易斯分校，对涉及金属的氢键的研究。将解决三个方面的问题。第一种是金属离子直接参与氢键。在这里，将研究早期过渡金属作为氢键受体。第二个领域涉及金属通过与能够形成氢键的配体的电子相互作用的间接影响。研究将集中在理解超分子结构中氢键的聚集。 最后，将研究金属配位几何形状在指导金属配合物的相互接近中的空间影响，所述金属配合物然后通过配体-配体氢键连接。 在这一领域，氢键在固态和晶体工程中的作用将使用配位和有机金属化合物组成的新化合物进行研究。最终目标是固态材料的合理设计和理解“金属壁”受体和通道的主客体化学。合成的化合物将通过溶液和固态光谱、单晶和粉末衍射研究、量热法、重量分析和计算建模来表征。氢键在化学和生物学中很重要，但它在有机金属化学、材料和生物无机化学中的作用还没有得到很好的理解，特别是因为它影响了新的领域，如超分子化学、自组装和晶体工程。 研究将集中在涉及金属的氢键上。 传统的研究考虑了非金属元素。 该研究有望更好地理解涉及金属的质子转移反应，新的氢键杂化有机-无机材料，以及涉及有机金属化合物的一类新的主体或通道结构。 学生将获得各种实验技术的经验，这将是非常宝贵的，因为他们在化学的新兴领域寻求职业生涯。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research by Lee Brammer, Chemistry Department, University of Missouri-St. Louis, on hydrogen bonds that involve metals. Three aspects will be addressed. The first is the direct involvement of metal ions in hydrogen bonding. Here, early transition metals will be studied as H-bond acceptors. The second area concerns the indirect influence of metals via electronic interaction with ligands capable of hydrogen bonding. Research will focus on understanding aggregation by hydrogen bonding in supramolecular structures. Finally, the spatial influence of metal coordination geometry in directing the mutual approach of metal complexes that are then linked via ligand-ligand hydrogen bonds will be studied. In this domain, the role of hydrogen bonding in solid state and crystal engineering will be investigated using new compounds composed of coordination and organometallic compounds. The ultimate objectives are the rational design of solid state materials and understanding host-guest chemistry of "metal-walled" receptors and channels. The compounds synthesized will be characterized by solution and solid state spectroscopy, single crystal and powder diffraction studies, calorimetry, gravimetric analysis, and computational modeling.Hydrogen bonding is important in chemistry and biology, but its role in organometallic chemistry, materials, and bioinorganic chemistry is not well understood, particularly as it affects new areas such as supramolecular chemistry, self-assembly, and crystal engineering. Research will be focused on hydrogen bonds that involve metals. Traditional studies have considered non-metal elements. The research is expected to lead to a better understanding of proton transfer reactions involving metals, new hydrogen-bonded hybrid organic-inorganic materials, and a new class of host or channel structures involving organometallic compounds. Students will gain experience in a variety of experimental techniques that will be invaluable as they seek careers in emerging areas of chemistry.