Immunobiology of the skin-specific receptor CLEC2A/KACL

皮肤特异性受体 CLEC2A/KACL 的免疫生物学

• 批准号: 138853536
• 负责人: Professor Dr. Alexander Luis Steinle
• 金额: --
• 依托单位: Institut für Molekulare Medizin
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/138853536?language=en
• 关键词: Immunobiology; skin; specific; receptor; CLEC2A

Natural Killer (NK) cells are lymphocytes of the innate immune system and were originally described due to their capacity to kill virus-infected or malignant 'self' cells. Subsequently, additional functions of NK cells became apparent such as secretion of cytokines, modulation of immune responses, and regulation of tissue homeostasis. Recently, additional types of innate lymphocytes were described that are rare in the peripheral blood, are characterized by a peculiar cytokine pattern and thought to be involved in tissue homeostasis. Reactivity of these innate lymphocytes is determined by cell surface receptors upon interaction with cognate ligands. Here, we propose to continue our studies on a novel and unique receptor/ligand pair where the receptor (NKp65) is expressed on a rare subset of innate lymphocytes, while expression of the ligand (KACL) is restricted to human keratinocytes as shown by our previous work. Here we plan to characterise NKp65-expressing lymphocytes in terms of phenotype and function, to address regulation of NKp65 expression, and to study functional consequences of NKp65/KACL interaction. From these studies, we do expect novel and significant insights into the biology and tissue-specific function of innate lymphocytes as well as into the immunobiology of human skin.

自然杀伤（NK）细胞是先天免疫系统的淋巴细胞，最初被描述是由于它们能够杀死病毒感染或恶性“自身”细胞。随后，NK细胞的其他功能变得明显，例如分泌细胞因子、调节免疫应答和调节组织稳态。最近，描述了在外周血中罕见的其他类型的先天性淋巴细胞，其特征在于特有的细胞因子模式，并被认为参与组织稳态。这些先天性淋巴细胞的反应性由与同源配体相互作用后的细胞表面受体决定。在这里，我们建议继续我们的研究一个新的和独特的受体/配体对受体（NKp 65）是先天性淋巴细胞的一个罕见的子集上表达，而表达的配体（KACL）被限制到人类角质形成细胞，如我们以前的工作所示。在这里，我们计划研究NKp 65表达淋巴细胞的表型和功能，以解决NKp 65表达的调控，并研究NKp 65/KACL相互作用的功能后果。从这些研究中，我们确实期望对先天淋巴细胞的生物学和组织特异性功能以及人类皮肤的免疫生物学有新的和重要的见解。

项目成果

BACL Is a Novel Brain-Associated, Non-NKC-Encoded Mammalian C-Type Lectin-Like Receptor of the CLEC2 Family

BACL 是 CLEC2 家族的一种新型脑相关、非 NKC 编码的哺乳动物 C 型凝集素样受体

• DOI: 10.1371/journal.pone.0065345
• 发表时间: 2013
• 期刊: PLoS ONE
• 影响因子: 3.7
• 作者: O. Lysenko;D. Schulte;M. Mittelbronn;A. Steinle
• 通讯作者: A. Steinle

Dedicated immunosensing of the mouse intestinal epithelium facilitated by a pair of genetically coupled lectin-like receptors

由一对基因耦合的凝集素样受体促进的小鼠肠上皮的专用免疫传感

• DOI: 10.1038/mi.2014.60
• 发表时间: 2015
• 期刊: Mucosal Immunology
• 影响因子: 8
• 作者: S. Leibelt;M.E. Friede;C. Rohe;D. Gutle;E. Rutkowski;A. Weigert;L. Kveberg;J.T. Vaage;M.W. Hornef;A. Steinle
• 通讯作者: A. Steinle

Vis-à-Vis in the NKC: Genetically Linked Natural Killer Cell Receptor/Ligand Pairs in the Natural Killer Gene Complex (NKC)

NKC 中的 Vis-à-Vis：自然杀伤基因复合体 (NKC) 中基因相关的自然杀伤细胞受体/配体对

• DOI: 10.1159/000324112
• 发表时间: 2011
• 期刊: Journal of Innate Immunity
• 影响因子: 5.3
• 作者: Vogler;A. Steinle
• 通讯作者: A. Steinle

Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium

Clr-a：一种由小鼠肠道上皮独家表达的新型免疫相关 C 型凝集素样分子

• DOI: 10.4049/jimmunol.1600666
• 发表时间: 2017
• 期刊: The Journal of Immunology
• 作者: E. Rutkowski;S. Leibelt;C. Born;M.E. Friede;S. Bauer;S. Weil;J. Koch;A. Steinle
• 通讯作者: A. Steinle