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Engineering Enhanced Anti-Apoptosis Activity for Mammalian Cell Culture

Engineering Enhanced Anti-Apoptosis Activity for Mammalian Cell Culture
工程增强哺乳动物细胞培养的抗凋亡活性
批准号：
0001967
负责人：
Michael Betenbaugh
金额：
$57.59万
依托单位：
Johns Hopkins University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-03-15 至 2005-02-28
来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0001967&HistoricalAwards=false
关键词：
EngineeringEnhancedAntiApoptosisActivity

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英文摘要
The objective of this project is to increase the lifetime of mammalian cells in culture by limiting apoptosis through genetic engineering. Specifically, anti-apoptosis genes will be modified to prevent their degradation in culture. The rationale is that much mammalian cell death in bioreactors is apoptotic and therefore represents a mechanism for increasing culture lifetimes. This would reduce productivity costs and make cell culture processes feasible for a larger number of products. This project will develop stable inhibitors for apoptosis for a wide range of mammalian hosts such as Chinese Hamster Ovary and Baby Hamster Kidney cell lines.
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