Planning Grant for BioMolecular Interaction Technology Center

生物分子相互作用技术中心规划资助

• 批准号: 0002962
• 负责人: Thomas Laue
• 金额: $ 1万
• 依托单位: University of New Hampshire
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0002962&HistoricalAwards=false
• 关键词: Planning; Grant; BioMolecular; Interaction; Technology

The pharmaceutical and biotechnology industries play a vital role in maintaining and promoting a healthy population, and constitute a major sector of the US economy. These industries have evolved from the empirical treatment of disease to a sophisticated approach for drug development which requires a deeper understanding of the biochemistry of life processes. As a consequence, the accurate description of biomolecular interactions has become a central element in understanding disease mechanisms, and now is an essential ingredient for devising safe and effective pharmaceuticals. A variety of instruments and methods are used to characterize biomolecular interactions. One group of these technologies, used physical first principles for their analysis. These first principle techniques could be used to address a great many needs in the pharmaceutical and biotechnology industries than they currently do. Meanwhile, the development of prototype instruments and methods for characterizing molecular interactions is being pursued in the academic world.While some of these developments have been commercialized, others, mostly due to their limited market size, have remained prototypes in academic laboratories. These prototypes, while suitable for addressing academic questions, are not optimized for industrial uses, and are housed in laboratories that do not provide the level of security required by industry. Consequently, a barrier to technology transfer has developed. The formation of an NSF Industry/University Cooperative Research Center is an ideal mechanism for overcoming this barrier and advancing the field of molecular interaction science.

制药和生物技术行业在维持和促进人口健康方面发挥着至关重要的作用，是美国经济的主要部门。 这些行业已经从疾病的经验治疗发展为复杂的药物开发方法，这需要对生命过程的生物化学有更深入的了解。 因此，生物分子相互作用的准确描述已成为理解疾病机制的核心要素，现在也是设计安全有效的药物的重要组成部分。 多种仪器和方法用于表征生物分子相互作用。 其中一组技术使用物理第一原理进行分析。 这些第一原理技术可用于满足制药和生物技术行业比目前更多的需求。 与此同时，学术界正在致力于开发表征分子相互作用的原型仪器和方法。虽然其中一些开发已经商业化，但其他开发主要由于其市场规模有限，仍停留在学术实验室中的原型。 这些原型虽然适合解决学术问题，但并未针对工业用途进行优化，并且位于不提供工业所需安全级别的实验室中。 因此，技术转让的障碍已经形成。 NSF工业/大学合作研究中心的成立是克服这一障碍并推进分子相互作用科学领域的理想机制。