SGER: Piezoelectric Cantilevers for Nanoscale Biosensing

普林斯顿大学的伊尔汗·阿克赛这项建议旨在明确允许设计和制造一类新的微型传感器的基本过程。它们将结合压电微悬臂梁、纳米结构涂层(例如纳米多孔二氧化硅)和生物探测器。它们的灵敏度应该比现有的压电式传感器高出约100倍。然后，PI们对他们认为在设计师可以依赖可靠的通用信息之前应该探索的关键基本问题进行了极其详细的讨论：1)通过溶胶/凝胶化学和软光刻生产尺寸减小的微悬臂梁阵列，作为从给定样本中收集更多同步和实时生物特性(例如血液中的生物特性)的一种方式。预计二氧化硅孔隙度的增强作用将是主要的(最高可达500m2/克)。其中一个特别令人感兴趣的应用将是活体情况下的生物传感器微阵列技术。2)建议的其余部分涉及这些诊断技术的关键组件的最新技术和拟议的研究偏离：传感器性能(压电微悬臂梁和纳米结构涂层)、陶瓷与石英、微制造、建模和尺寸效应、生物分子在纳米多孔介质中的行为。

AbstractCTS-0003882Ilhan Aksay, Princeton UniversityThis proposal aims at clearing the fundamental processes which will permit the design and construction of a new class of microsensors. These will combine piezoelectric microcantilevers, nanostructured coatings (e.g. nanoporous silica), and biological detectors. Their sensitivity should outperform existing piezoactive sensors by a factor of about 100. The PI's have then engaged into an extremely detailed discussion of the key basic questions they felt should be explored before designers could depend on reliable, generic information: 1) the production of arrays of reduced-size microcantilever by sol/gel chemistry and soft lithography, as a way to collect from a given sample, many more simultaneous and real time bio-properties (e.g. in blood). The enhancing effect of silica porosity is expected to be a major one (up to 500 m2/gram). One application of special interest would be, among others, the technology of biosensor microarrays for in vivo situations. 2) the bulk of the remainder of the proposal concerns the state of the art and proposed research departures of the key components of these diagnostics techniques: sensor performance (piezoelectric microcantilevers and nanostructures coatings), ceramics vs. quarts, micromanufacturing, modeling and size effects, biomolecules behavior in nanoporous media.