CISE Postdoctoral Research Associates in Experimental Computer Science - Probing Neural Substrates of Behavior

CISE 实验计算机科学博士后研究员 - 探索行为的神经基础

• 批准号: 0072744
• 负责人: Karl Bohringer
• 金额: $ 7.1万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0072744&HistoricalAwards=false
• 关键词: CISE; Postdoctoral; Research; Associates; Experimental

EIA-0072744Bohringer, KarlUniversity of WashingtonCISE Postdoctoral Associates in Experimental Computer Science: ProbingNeural Substrates of BehaviorThe focus of our multi-disciplinary research program is the development oftools and techniques for multisite intracellular recording in freelybehaving animals. More specifically, we are involved in amulti-investigator effort to implant a microcomputer into the brain of amarine mollusk, for the purpose of recording neuronal signals. This effortcomprises three main thrusts: (1) to develop silicon microcomputers thatcan record from, and communicate with, multiple neurons in an intactanimal; (2) to develop multi-site intracellular probe arrays, and thetechniques for attaching these arrays to nervous tissue without damagingeither probes or tissue; and (3) to develop neurophysiological preparationsand techniques for surgically implanting both microchips and probe arraysin live, freely behaving animals, and for recording from these animals intheir natural environment for several hours.

EIA-0072744华盛顿大学Bohringer在实验计算机科学方面的博士后助理：行为的神经基础我们多学科研究计划的重点是开发在自由行为的动物中进行多点细胞内记录的工具和技术。更具体地说，我们参与了多名研究人员的努力，将微型计算机植入海洋软体动物的大脑，以记录神经元信号。这项工作包括三项主要工作：(1)开发能够记录完整动物中多个神经元并与其通信的硅微型计算机；(2)开发多点细胞内探针阵列，以及将这些阵列连接到神经组织而不损害探针或组织的技术；以及(3)开发神经生理学准备和技术，用于在活体、自由行为的动物中通过外科手术植入微芯片和探针阵列，并在自然环境中记录这些动物的数据。