CISE Postdoctoral Research Associates in Experimental Computer Science - Probing Neural Substrates of Behavior

bohringer， karl华盛顿大学cise实验计算机科学博士后助理：探测行为的神经基础我们多学科研究计划的重点是开发用于自由行为动物的多位点细胞内记录的工具和技术。更具体地说，我们正在参与一项由多个研究人员组成的努力，将微型计算机植入海洋软体动物的大脑，以记录神经元信号。这一努力包括三个主要方面：(1)开发能够记录完整动物的多个神经元并与之交流的硅微型计算机；(2)开发多位点细胞内探针阵列，以及在不损伤探针或组织的情况下将这些阵列连接到神经组织的技术；(3)发展神经生理学的准备和技术，以外科手术将微芯片和探针阵列植入活的、自由行为的动物体内，并在这些动物的自然环境中记录几个小时。

EIA-0072744Bohringer, KarlUniversity of WashingtonCISE Postdoctoral Associates in Experimental Computer Science: ProbingNeural Substrates of BehaviorThe focus of our multi-disciplinary research program is the development oftools and techniques for multisite intracellular recording in freelybehaving animals. More specifically, we are involved in amulti-investigator effort to implant a microcomputer into the brain of amarine mollusk, for the purpose of recording neuronal signals. This effortcomprises three main thrusts: (1) to develop silicon microcomputers thatcan record from, and communicate with, multiple neurons in an intactanimal; (2) to develop multi-site intracellular probe arrays, and thetechniques for attaching these arrays to nervous tissue without damagingeither probes or tissue; and (3) to develop neurophysiological preparationsand techniques for surgically implanting both microchips and probe arraysin live, freely behaving animals, and for recording from these animals intheir natural environment for several hours.