POWRE: Early Experience and Neurosteroid Response to Stress: A Behavioral Neuroscience Laboratory Enhancement Project

POWRE:早期经验和神经类固醇对压力的反应:行为神经科学实验室增强项目

基本信息

  • 批准号:
    0074627
  • 负责人:
  • 金额:
    $ 7.49万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-09-15 至 2002-08-31
  • 项目状态:
    已结题

项目摘要

Why can some people respond quickly in stressful situations, calm down and think clearly, while others are immobilized with fear and anxiety? Are early childhood experiences responsible for these individual differences in emotional and cognitive coping behaviors? Although much is known about the physiological stress responses in the body, there is very little evidence about how the brain responds to stress. And while it is evident that children who experience traumatic events have trouble learning and coping, there is very little information about compensatory mechanisms and the role of early experience in organizing these pathways. Professor Zimmerberg proposes that a "stress compensatory" system may be mediated by the neurosteroid 3-alpha-hydroxy, 5-alpha-pregnan-20-one (allopregnanolone), a progesterone metabolite synthesized in the brains of both males and females in response to stress. She has established that this progesterone metabolite reduces fearful behavior in novel, stressful situations in both young and adult subjects. Individual differences in the allopregnanolone-modulated stress response in neonates and adults were demonstrated to be influenced by both pre- and post-natal stress experiences, as well as by selective breeding. This grant will elucidates one possible mechanism underlying the short and long-term consequences of early stress by studying neurosteroid/GABAa binding parameters in selected brain regions.This research will lead to a better understanding of the neural mechanisms underlying our ability to dampen the physiological responses to fearful or overwhelming situations so we can adapt and develop more calm and cogent reactions. In a society where stress leads too often to rage, understanding the basic biological responses to stress and their control will have broad benefits to educators, parents, and public policy makers.The POWRE activities are organized around extended visits to two host institutions to allow Dr. Zimmerberg, who is stepping down from major administrative and curricular demands at a small undergraduate college, to upgrade her teaching and research at a critical mid-career stage. At the Center for Behavioral Neuroscience at Emory University, she will gain mastery of new molecular and imaging approaches, which are advancing the study of behavior. Second, a new international collaboration with the Laboratory of Experimental Neurobiology at the University of Cagliari will be established as part of this project.
为什么有些人能在紧张的情况下迅速反应,冷静下来,清晰地思考,而另一些人则因恐惧和焦虑而无法动弹? 幼儿期的经历是否是造成情绪和认知应对行为个体差异的原因? 虽然我们对身体的生理应激反应了解很多,但关于大脑如何应对压力的证据却很少。 虽然很明显,经历创伤性事件的儿童在学习和应对方面存在困难,但关于补偿机制以及早期经验在组织这些途径中的作用的信息很少。 Zimmerberg教授提出,一个“压力补偿”系统可能是由神经类固醇3-α-羟基,5-α-胆甾烷-20-酮(allopregnanolone)介导的,这是一种孕酮代谢物,在男性和女性的大脑中合成,以应对压力。 她已经确定,这种孕酮代谢物可以减少年轻人和成年人在新的压力情况下的恐惧行为。 在新生儿和成人的allopregnanolone调制的应激反应的个体差异被证明是产前和产后的压力的经验,以及通过选择性繁殖的影响。 该基金将通过研究选定大脑区域的神经类固醇/GABAa结合参数,阐明早期压力的短期和长期后果的一种可能机制。这项研究将有助于更好地了解我们抑制恐惧或压倒性情况下的生理反应的神经机制,以便我们能够适应和发展更平静和有说服力的反应。 在一个压力往往导致愤怒的社会中,了解压力的基本生物反应及其控制将对教育工作者、家长和公共政策制定者产生广泛的好处。POWRE活动是围绕对两个主办机构的长期访问而组织的,以便让Zimmerberg博士能够从一所小型本科院校的主要行政和课程需求中解脱出来,提升她的教学和研究在一个关键的职业生涯中期阶段。 在埃默里大学行为神经科学中心,她将掌握新的分子和成像方法,这是推进行为的研究。 第二,作为该项目的一部分,将与卡利亚里大学实验神经生物学实验室建立新的国际合作。

项目成果

期刊论文数量(0)
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Betty Zimmerberg其他文献

Changes in side preference during unilateral electrical stimulation of the caudate nucleus in rats
  • DOI:
    10.1016/0006-8993(75)90707-6
  • 发表时间:
    1975-03-21
  • 期刊:
  • 影响因子:
  • 作者:
    Betty Zimmerberg;Stanley D. Glick
  • 通讯作者:
    Stanley D. Glick

Betty Zimmerberg的其他文献

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{{ truncateString('Betty Zimmerberg', 18)}}的其他基金

Multimedia Neuroscience Education
多媒体神经科学教育
  • 批准号:
    9653051
  • 财政年份:
    1997
  • 资助金额:
    $ 7.49万
  • 项目类别:
    Standard Grant

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