FASEB Summer Conference on Phospholipases to be held July 9-13, 2000 in Snowmass Village, Colorado

莱斯利0075879这笔赠款是为FASEB关于磷脂酶的夏季研究会议提供部分支持。会议旨在综述磷脂酶A2、C和D的结构、功能和调控的现状。这些普遍存在的酶通过产生介导不同细胞反应的脂类产物来触发主要的信号转导途径。磷脂酶A2酶释放花生四烯酸，花生四烯酸是产生二十烷类化合物和血小板激活因子的第一步，这两种物质是炎症介质。磷脂酶C酶介导多聚磷肌醇和二酰甘油的产生，调节钙水平和蛋白激酶C。磷脂酶D酶由磷脂酰胆碱产生磷脂酸，参与调节囊泡运输、有丝分裂、呼吸爆发氧化酶和其他酶。这次会议将汇聚酶学家和分子细胞生物学家，为深入的科学讨论提供机会。它还将促进年轻研究人员和资深科学家之间的互动。

Leslie0075879This grant is for partial support for a FASEB Summer Research Conference on Phospholipases. The conference aims to review the current status of what is known about the structure, function and regulation of phospholipases A2, C and D. These ubiquitous enzymes trigger major signal transduction pathways by producing lipid products that mediate diverse cellular responses. Phospholipase A2 enzymes release arachidonic acid, which is the first step in the production of the eicosanoids and platelet activation factor, which are inflammatory mediators. Phospholipase C enzymes mediate the production of polyphosphoinositols and diacylglycerols, which regulate calcium levels and protein kinase C. Phospholipase D enzymes produce phosphatidic acid from phosphatidylcholine and are implicated in regulating vesicle trafficking, mitogenesis, respiratory burst oxidase and other enzymes. This conference will bring together enzymologists and molecular cell biologists to provide an opportunity for in depth scientific discussions. It will also promote interactions between young investigators and senior scientists.