Acquisition of an Electron Paramagnetic Resonance Spectrometer for Chemical Research

购买用于化学研究的电子顺磁共振波谱仪

• 批准号: 0077939
• 负责人: David Ewing
• 金额: $ 11.88万
• 依托单位: John Carroll University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0077939&HistoricalAwards=false
• 关键词: Acquisition; Electron; Paramagnetic; Resonance; Spectrometer

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at John Carroll University will acquire an Electron Paramagnetic Resonance (EPR) Spectrometer. The new instrument will support the research of major users at both John Carroll University and Youngstown State University. Among the research programs in which EPR spectroscopy will play a vital role are: 1) probing the active site of blue copper proteins; b) systematic study of titatnium (III) in the presence of biologically relevant ligands and a spin-trap; c) structural analysis of an iron-sulfur cluster associated with cytoplasmic aconitase; d) investigation of the electronic states of novel thiovanadyl complexes and new radical anions of cyanoacacarbons; e) determination of high or low-spin crossover in manganese and chromium metallocenophane complexes; and f) analysis of redox states of doped rutile pigments.An electron paramagnetic resonance (EPR) spectrometer is an instrument used to obtain information about the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals which are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, especially biochemistry.

有了化学研究仪器和设施(CRIF)计划的这一奖项，约翰·卡罗尔大学化学系将获得一台电子顺磁共振(EPR)光谱仪。新仪器将支持约翰·卡罗尔大学和扬斯敦州立大学主要用户的研究。EPR光谱将在以下研究项目中发挥重要作用：1)探测蓝色铜蛋白的活性位置；b)在生物相关配体和自旋陷阱存在的情况下对钛(III)进行系统研究；c)与细胞质乌头酸酶相关的铁硫簇合物的结构分析；d)研究新型硫钒络合物和氰化钾的新自由基阴离子的电子态；e)测定锰和铬的金属茂金属络合物中的高自旋或低自旋交叉；F)分析掺杂金红石颜料的氧化还原状态。电子顺磁共振(EPR)光谱仪是一种用于获得分子和电子结构信息的仪器。它还可以用来获得有关自由基寿命的信息，这些自由基通常是启动肿瘤生长和/或各种化学反应所必需的。这些研究将在许多领域产生影响，特别是生物化学。