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MRI: Acquisition of a Variable Temperature (3.8-300 K) X-Band Electron Paramagnetic Resonance Spectrometer

MRI：变温 (3.8-300 K) X 波段电子顺磁共振波谱仪的采集

基本信息

批准号：
1920110
负责人：
Roman Dembinski
金额：
$ 28.98万
依托单位：
Oakland University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1920110&HistoricalAwards=false
关键词：
MRI Acquisition Variable Temperature 3.8

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. Professor Roman Dembinski from Oakland University and colleagues Xiangqun Zeng, Ferman Chavez, Wei Zhang and Amitava Adhikary are acquiring a variable-temperature, continuous-wave-X-band-electron paramagnetic resonance (EPR) spectrometer. In general, an EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid-state materials. It is also used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of possible pathological growth. These studies impact several areas, from the synthesis of inorganic and organic molecules to the development of new solid-state materials to compounds of magnetic and biological interest. Employing examples inspired from ongoing research, this instrument is an integral part of research and teaching at the undergraduate and graduate levels at Oakland University. Additionally, the investigators are sharing the spectrometer with many interested users from the area. The instrumentation strengthens the institution's educational mission in the chemical, biochemical, and environmental sciences, which involves students from a broad range of ethnic and cultural backgrounds in southeastern Michigan. The student users include socio-economically disadvantaged and minority students in the Detroit metropolitan area.The award of this spectrometer is aimed at enhancing research and education at all levels. The instrument acquisition is especially useful in understanding the mechanisms of reactions involving free radical damage to biomolecules and its repair and/or restitution. The instrument is also employed in investigations of the roles of metallo-peptides involved in reactive oxygen species formation and in research of feromagnetic-coupled systems for materials science. The instrumentation serves researchers studying free-radical-mediated redox processes in molecules dissolved in ionic liquids, and those trying to understand the role of free radicals such as superoxide anion radical that are related to the onset of maturity of human cataracts.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。来自奥克兰大学的Roman Dembinski教授和他的同事曾向群、Ferman Chavez、张伟和Amitava Adhikary正在获得一种变温、连续波x波段电子顺磁共振（EPR）光谱仪。一般来说，EPR光谱仪产生分子和固态材料的几何和电子结构的详细信息。它还用于获取有关自由基的寿命的信息，这些自由基是短命的、高活性的物质，参与有价值的化学转化，以及可能的病理生长的开始。这些研究影响了几个领域，从无机和有机分子的合成到新型固态材料的开发，再到磁性和生物学的化合物。该仪器从正在进行的研究中获得灵感，是奥克兰大学本科生和研究生研究和教学中不可或缺的一部分。此外，研究人员正在与该地区的许多感兴趣的用户共享光谱仪。该仪器加强了该机构在化学、生化和环境科学方面的教育使命，涉及来自密歇根州东南部广泛的种族和文化背景的学生。学生用户包括底特律大都市区的社会经济弱势群体和少数民族学生。该光谱仪的颁发旨在加强各级的研究和教育。仪器采集在了解自由基损伤生物分子及其修复和/或恢复的反应机制方面特别有用。该仪器还用于研究金属肽在活性氧形成中的作用，以及材料科学中铁磁耦合系统的研究。该仪器服务于研究溶解在离子液体中的分子中自由基介导的氧化还原过程的研究人员，以及那些试图了解自由基（如超氧阴离子自由基）与人类白内障成熟发病有关的作用的研究人员。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

One-electron oxidation of ds(5'-GGG-3') and ds(5'-G(8OG)G-3') and the nature of hole distribution: a density functional theory (DFT) study.

ds(5-GGG-3) 和 ds(5-G(8OG)G-3) 的单电子氧化和空穴分布的性质：密度泛函理论 (DFT) 研究。

DOI：
10.1039/c9cp06244k
发表时间：
2020
期刊：
Physical chemistry chemical physics : PCCP
影响因子：
0
作者：
Kumar,Anil;Adhikary,Amitava;Sevilla,MichaelD;Close,DavidM
通讯作者：
Close,DavidM

Site of Azido Substitution in the Sugar Moiety of Azidopyrimidine Nucleosides Influences the Reactivity of Aminyl Radicals Formed by Dissociative Electron Attachment.

叠氮二嘧啶核苷的糖部分中叠氮化物的位点会影响解离电子附着形成的氨基基自由基的反应性。

DOI：
10.1021/acs.jpcb.0c08201
发表时间：
2020-12-17
期刊：
The journal of physical chemistry. B
影响因子：
0
作者：
Mudgal M;Dang TP;Sobczak AJ;Lumpuy DA;Dutta P;Ward S;Ward K;Alahmadi M;Kumar A;Sevilla MD;Wnuk SF;Adhikary A
通讯作者：
Adhikary A

Ne-22 Ion-Beam Radiation Damage to DNA: From Initial Free Radical Formation to Resulting DNA-Base Damage.

DOI：
10.1021/acsomega.1c01954
发表时间：
2021-06-29
期刊：
ACS omega
影响因子：
4.1
作者：
Kant M;Jaruga P;Coskun E;Ward S;Stark AD;Baumann T;Becker D;Adhikary A;Sevilla MD;Dizdaroglu M
通讯作者：
Dizdaroglu M

Comment un électron induit un dommage oxydatif dans l’ADN

在 ADN 中对电子器件进行评论