Carbon-Carbon Bond-Forming and Cleaving Stoichiometric and Catalytic Organometallic Reactions

这项研究的重点有三个方面。首先，我们将开展以锆为催化剂的烯烃对映体选择性碳铝化反应合成方法的研究。其次，我们将探讨与其他早期过渡金属形成的“ATE”络合物的化学，特别是在1，2-迁移性插入反应方面。第三，在锆催化的碳金属化和钯催化的交叉偶联反应中，类胡萝卜素和其他多共轭天然产物的合成将被用于合成类胡萝卜素和其他多共轭天然产物。有了这一新的奖项，有机和高分子化学计划将支持普渡大学化学系的Ei-ichi Negishi博士的研究。Negishi教授将专注于开发新的合成方法，使用早期过渡金属的有机过渡金属化合物，特别是锆和钛。反过来，这种方法将被用于制备具有有趣生物学特性的天然产品。这项工作对制药业和材料科学产生了更广泛的影响。此外，该项目是培养研究生的绝佳场所。

The foci of this research are threefold. First, the development of synthetic methodology using the Zr-catalyzed enantioselective carboalumination of alkenes will be carried out. Second, the chemistry of "ate" complexes of Zr, Ti and other early transition metals, especially in the area of 1,2-migratory insertion reactions will be probed. Third, Zr-catalyzed carbometallation and Pd-catalyzed cross coupling reactions will be used for the synthesis of carotenoids and other polyconjugated natural products.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Ei-ichi Negishi of the Department of Chemistry at Purdue University. Professor Negishi will focus his work on developing new synthetic methodology using organotransition metal compounds of early transition metals, especially zirconium and titanium. The methodology, in turn, will be used to prepare natural products having interesting biological properties. The work has broader impacts for the pharmaceutical industry and for materials science. Further, the project is an excellent venue for the training of graduate students.