Carbon-Carbon Bond-Forming and Cleaving Stoichiometric and Catalytic Organometallic Reactions

本研究的重点有三个方面。首先，将发展利用锆催化烯烃对映选择性碳铝化的合成方法。其次，将探讨Zr、Ti等早期过渡金属的“ate”配合物的化学性质，特别是1,2迁移插入反应的化学性质。第三，利用zr催化的碳金属化反应和pd催化的交叉偶联反应合成类胡萝卜素等多共轭天然产物。有了这个更新奖，有机和大分子化学项目支持普渡大学化学系根岸英一博士的研究。根岸教授将专注于开发新的合成方法，使用早期过渡金属的有机过渡金属化合物，特别是锆和钛。反过来，该方法将用于制备具有有趣生物学特性的天然产物。这项工作对制药工业和材料科学有更广泛的影响。此外，该项目是培养研究生的绝佳场所。

The foci of this research are threefold. First, the development of synthetic methodology using the Zr-catalyzed enantioselective carboalumination of alkenes will be carried out. Second, the chemistry of "ate" complexes of Zr, Ti and other early transition metals, especially in the area of 1,2-migratory insertion reactions will be probed. Third, Zr-catalyzed carbometallation and Pd-catalyzed cross coupling reactions will be used for the synthesis of carotenoids and other polyconjugated natural products.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Ei-ichi Negishi of the Department of Chemistry at Purdue University. Professor Negishi will focus his work on developing new synthetic methodology using organotransition metal compounds of early transition metals, especially zirconium and titanium. The methodology, in turn, will be used to prepare natural products having interesting biological properties. The work has broader impacts for the pharmaceutical industry and for materials science. Further, the project is an excellent venue for the training of graduate students.