New Carbon-Carbon Bond-Forming and -Cleaving Organometallic Reactions

新的碳-碳键形成和断裂有机金属反应

• 批准号: 9023728
• 负责人: Ei-ichi Negishi
• 金额: $ 32.4万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1994-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9023728&HistoricalAwards=false
• 关键词: New; Carbon; Bond; Forming; Cleaving

The Synthetic Organic Program will support the research of Dr. Ei-ichi Negishi of the Department of Chemistry at Purdue University. Dr. Negishi will continue his innovative studies on organometallic carbon-carbon bond forming reactions catalyzed or promoted by transition metal complexes, especially ones involving zirconium and hafnium. This study includes discovery and development of synthetically attractive new organometallic reactions and exploration of the scope and mechanism of funda- mental organometallic reaction patterns. Dr. Negishi will focus his research in four areas: (1) catalytic reactions of organozirconium and organohafnium compounds, (2) diastereoselective and enantioselective reactions of organozirconium and organohafnium compounds, (3) further exploration of the chemistry of zirconicene and hafnicene derivatives, and (4) stuctural and mechanistic studies of organozirconium and organohafnium compounds. In these studies Dr. Negishi will also systematically investigate the scope of migratory insertion reactions with emphasis on those involving d-block transition metals.

合成有机计划将支持博士的研究。 普渡大学化学系的根岸英一 大学根岸博士将继续他的创新研究， 有机金属碳-碳键形成反应催化 或由过渡金属络合物促进，特别是 包括锆和铪。这项研究包括发现 和开发具有综合吸引力的新型有机金属化合物 反应和探讨基金的规模和机制， 金属有机金属反应模式。 根岸博士的研究将集中在四个方面：（1） 有机锆和有机铪的催化反应 化合物，（2）非对映选择性和对映选择性 有机锆和有机铪化合物的反应，（3） 进一步探讨了锆英石的化学性质， （4）结构和机理 有机锆和有机铪化合物的研究。在 根岸博士还将系统地研究这些研究， 迁移插入反应的范围，重点是 涉及D区过渡金属的那些。