New Carbon-Carbon Bond Forming Organometallic Reactions

新的碳-碳键形成有机金属反应

• 批准号: 8921899
• 负责人: Ei-ichi Negishi
• 金额: $ 9.69万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-05-01 至 1991-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=8921899&HistoricalAwards=false
• 关键词: New; Carbon; Bond; Forming; Organometallic

The Synthetic Organic Program will support the research of Dr. Ei-ichi Negishi of the Department of Chemistry at Purdue University. Dr. Negishi will continue his innovative studies on organometallic carbon-carbon bond forming reactions catalyzed or promoted by transition metal complexes. This study includes discovery and development of synthetically attractive new organometallic reactions and exploration of the scope and mechanism of fundamental organometallic reaction patterns. Dr. Negishi will focus on the chemistry of low-electron-count metallocenes containing titanium, zirconium and hafnium wherein a wide variety of novel skeletal rearangements and migratory insertions are anticipated. Another major thrust is the study of migratory insertions arising from the reactions of alpha-halo-alpha-silylalkyllithiums with organotransition metals. The synthetic aspects of palladium- or nickel-catalyzed cross coupling reactions and efforts to develop useful carbometallation reactions involving titanium, zirconium, nickel, palladium and copper are other areas of interest.

合成有机项目将支持普渡大学化学系根岸英一博士的研究。根岸博士将继续在过渡金属配合物催化或促进的有机金属碳-碳键形成反应方面进行创新研究。本研究包括发现和发展具有合成吸引力的有机金属新反应，探索基本有机金属反应模式的范围和机理。根岸博士将专注于含钛、锆和铪的低电子数茂金属的化学研究，其中预计会出现各种各样的新型骨骼重排和迁移插入。另一个主要的推力是研究由α -晕- α -硅烷基锂与有机过渡金属的反应引起的迁移插入。钯或镍催化的交叉偶联反应的合成方面以及开发有用的涉及钛、锆、镍、钯和铜的碳金属化反应的努力是其他感兴趣的领域。