New Carbon-Carbon Bond-Forming and -Cleaving Organometallic Reactions

新的碳-碳键形成和断裂有机金属反应

• 批准号: 9704994
• 负责人: Ei-ichi Negishi
• 金额: $ 47.35万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9704994&HistoricalAwards=false
• 关键词: New; Carbon; Bond; Forming; Cleaving

The focus of this research is three-fold. First the enantioselective carboalumination of unactivated terminal alkenes will be developed. Second, several zirconium- and titanium-catalyzed reactions will be probed. Third, the ring opening reactions of zirconacycles with single-bonded reagents will be investigated. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Ei-Ichi Negishi of the Department of Chemistry at Purdue University. Professor Negishi will focus his work on the development of new synthetically useful organic transformations via organometals with emphasis on catalysis and selectivity. The approach will lead to the production of methodology which can be utilized for the synthesis of natural products, compounds with interesting biological properties and compounds of interest to materials chemistry.

本研究的重点有三个方面。首先，将开发未活化的末端烯烃的对映选择性碳铝化反应。其次，我们将探讨几种由锆和钛催化的反应。第三，研究了锆英石与单键试剂的开环反应。有了这个更新的奖项，合成有机计划将支持普渡大学化学系的Ei-Ichi Negishi博士的研究。Negishi教授将专注于通过有机金属进行新的合成有用的有机转化的开发，重点是催化和选择性。该方法将产生可用于合成天然产物、具有感兴趣的生物学特性的化合物和材料化学感兴趣的化合物的方法学。