PECASE: Analysis of Novel Composite Tissue Engineered Systems

PECASE：新型复合组织工程系统的分析

• 批准号: 0093805
• 负责人: Karen Burg
• 金额: $ 37.5万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0093805&HistoricalAwards=false
• 关键词: PECASE; Analysis; Novel; Composite; Tissue

0093805Karen BurgResearch and development of engineered tissue has potential widespread medical application, including lumpectomy reconstruction, liver repair, cartilage replacement, or other conditions. Tissue engineering involves taking a small number of healthy cells from a patient, growing the cells into large numbers in a laboratory environment, combining them with an absorbable (similar to biodegradable) material that has been sculpted into the anatomical shape of the injured part, allowing the cells to develop, implanting the cell-material system into the patient, and then allowing the cells to grow and acquire the original anatomical shape. The material gradually breaks down, is "absorbed" by the body, and is thus removed.The proposed 5-year work is a focus on the basic science of breast tissue engineering for cancer patients who have undergone a mastectomy or lumpectomy. The effort will be to develop a program in tissue engineering, encompassing the research and development of new injectable materials and training of graduate and undergraduate students. It also will promote public awareness of bioengineering and critical thinking through the development of a K-12 educational outreach program, a program developed through the combined efforts of the Department of Bioengineering and the Department of Education at Clemson University. The mission of the proposed research is to present and justify a new materials approach to tissue engineering. It is hypothesized that by providing a two-phase, composite, injectable material, cell growth and tissue development may be enhanced within a clinically viable solution. Previous studies by the applicant have demonstrated general efficacy of such systems, but have not encompassed a careful assessment of the components. A selection of crafted materials of varying proportions will be addressed and the research will be conducted using a comprehensive battery of mechanical and chemical tests to assess the systems. The success of the basic research concept relies on a well-orchestrated research plan, as well as on education of the involved scientists and future scientists. The science and technology derived from this work will be transferred to other clinical applications presenting similar requirements.

0093805 Karen Burg工程组织的研究和开发具有潜在的广泛的医疗应用，包括肿块切除术重建，肝脏修复，软骨置换或其他情况。 组织工程包括从病人身上取少量健康细胞，在实验室环境中使细胞大量生长，将它们与可吸收的（类似于可生物降解的）材料，其已经被雕刻成受伤部位的解剖形状，允许细胞发育，将细胞-材料系统植入患者体内，然后让细胞生长并获得原始的解剖形状。 材料逐渐分解，被身体“吸收”，从而被去除。拟议的5年工作重点是为接受乳房切除术或乳房肿块切除术的癌症患者提供乳房组织工程的基础科学。 这项工作将是开发一个组织工程计划，包括研究和开发新的可注射材料和培训研究生和本科生。 它还将通过制定K-12教育推广计划，促进公众对生物工程和批判性思维的认识，该计划是通过克莱姆森大学生物工程系和教育系的共同努力制定的。 拟议的研究的使命是提出和证明一种新的材料方法的组织工程。 假设通过提供两相复合可注射材料，可以在临床上可行的溶液中增强细胞生长和组织发育。 申请人之前的研究已经证明了此类系统的一般有效性，但尚未包括对组分的仔细评估。 将讨论不同比例的手工材料的选择，并将使用一系列全面的机械和化学测试来评估系统。 基础研究概念的成功依赖于精心策划的研究计划，以及对参与研究的科学家和未来科学家的教育。 从这项工作中获得的科学和技术将被转移到提出类似要求的其他临床应用中。