Genome-wide association study for attention deficit/ hyperactivity disorder

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Genome wide association studies (GWAS) recently led to the identification of various polygenes for different complex disorders. Heritability for attention-deficit/hyperactivity disorder (ADHD) is high (approximately 0.8). We had previously performed genome wide linkage scans for ADHD. For the peak region on chromosome 5p we found linkage and association to the dopamine transporter gene. Here we aim to identify additional genes relevant for ADHD by a systematic GWAS approach in 808 young patients (here we apply for funding of 450 of these) and 2,144 epidemiological controls (n=1,644 from KORA and n=500 from POPGEN). The 50 best single nucleotide polymorphisms (SNPs) identified by the GWAS and the 20 best copy number polymorphisms (CNPs) will be chosen for confirmation in 2,200 additional independent ADHD trios, provided by co-operation partners and in 600 adult patients with ADHD. Subsequently, we will analyze the validated SNPs/CNPs in silico e.g. for haplotype structure and functional implications.