NIRT/GOALI: DNA-Based Nanomechanical Devices

NIRT/GOALI：基于 DNA 的纳米机械装置

• 批准号: 0103002
• 负责人: Nadrian Seeman
• 金额: $ 150万
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0103002&HistoricalAwards=false
• 关键词: NIRT; GOALI; DNA; Based; Nanomechanical

AbstractCTS-0103002N. Seeman, et al., New York UniversityThis proposal was received in response to Nanoscale Science and Engineering (NSE) solicitation, NSF-00119, in the category Nanoscale Interdisciplinary Research Teams (NIRT). This is a collaborative activity between New York University, California Institute of Technology and Dow Chemical Co. using GOALI model. The goal is to synthesize and demonstrate operational nanoscale machines or devices. The level of control offered by DNA systems can be exploited to make intricate DNA nanostructures, including self-assembling DNA that forms two-dimensional and three-dimensional arrays. Modeling and simulation is a critical part of this project, in order construct and test the DNA nanostructures. It is proposed to combine the activities of New York University, California Institute of Technology and Dow Chemical laboratories to achieve a demonstration of DNA based nanomechanical devices useful for performing fast calculations, for sensors that detect specific molecules in the environment, or to improve the properties or performance of a material. Practical design and manufacture of nanoscale machines and devices requires overcoming numerous challenges in synthesis, processing, characterization, design, optimization, and fabrication. The approach will be first to prototype the designs computationally, optimizing the particular base-pair sequences, making sure that the particular lengths and spacings will lead to proper clearances, and testing the operation of the device, including the dynamics. The project will focus on nanomechanical devices of three types. o The B-Z based nanomotor. A DNA based nanomotor predicated on the B to Z DNAtransitions under different salt conditions. o A DNA sequence-specific mechanical device o A DNA based switch based on principles similar to the DNA sequence-specific mechanical device.

摘要CTS-0103002N。 Seeman 等人，纽约大学此提案是为了响应纳米级跨学科研究团队 (NIRT) 类别中的纳米科学与工程 (NSE) 征集 NSF-00119 而收到的。 这是纽约大学、加州理工学院和陶氏化学公司利用 GOALI 模型合作开展的活动。 目标是合成并演示可操作的纳米级机器或设备。 DNA 系统提供的控制水平可用于制造复杂的 DNA 纳米结构，包括形成二维和三维阵列的自组装 DNA。 为了构建和测试 DNA 纳米结构，建模和模拟是该项目的关键部分。建议将纽约大学、加州理工学院和陶氏化学实验室的活动结合起来，以实现基于 DNA 的纳米机械装置的演示，该装置可用于执行快速计算、检测环境中特定分子的传感器或改善材料的特性或性能。 纳米级机器和设备的实际设计和制造需要克服合成、加工、表征、设计、优化和制造方面的众多挑战。 该方法将首先通过计算对设计进行原型设计，优化特定的碱基对序列，确保特定的长度和间距将导致适当的间隙，并测试设备的操作，包括动力学。 该项目将重点研究三种类型的纳米机械装置。 o 基于 B-Z 的纳米电机。 基于 DNA 的纳米电机基于不同盐条件下的 B 到 Z DNA 转变。 o DNA 序列特定机械装置 o 基于 DNA 的开关，其原理与 DNA 序列特定机械装置类似。