NIRT/GOALI: DNA-Based Nanomechanical Devices
NIRT/GOALI:基于 DNA 的纳米机械装置
基本信息
- 批准号:0103002
- 负责人:
- 金额:$ 150万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-08-01 至 2005-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
AbstractCTS-0103002N. Seeman, et al., New York UniversityThis proposal was received in response to Nanoscale Science and Engineering (NSE) solicitation, NSF-00119, in the category Nanoscale Interdisciplinary Research Teams (NIRT). This is a collaborative activity between New York University, California Institute of Technology and Dow Chemical Co. using GOALI model. The goal is to synthesize and demonstrate operational nanoscale machines or devices. The level of control offered by DNA systems can be exploited to make intricate DNA nanostructures, including self-assembling DNA that forms two-dimensional and three-dimensional arrays. Modeling and simulation is a critical part of this project, in order construct and test the DNA nanostructures. It is proposed to combine the activities of New York University, California Institute of Technology and Dow Chemical laboratories to achieve a demonstration of DNA based nanomechanical devices useful for performing fast calculations, for sensors that detect specific molecules in the environment, or to improve the properties or performance of a material. Practical design and manufacture of nanoscale machines and devices requires overcoming numerous challenges in synthesis, processing, characterization, design, optimization, and fabrication. The approach will be first to prototype the designs computationally, optimizing the particular base-pair sequences, making sure that the particular lengths and spacings will lead to proper clearances, and testing the operation of the device, including the dynamics. The project will focus on nanomechanical devices of three types. o The B-Z based nanomotor. A DNA based nanomotor predicated on the B to Z DNAtransitions under different salt conditions. o A DNA sequence-specific mechanical device o A DNA based switch based on principles similar to the DNA sequence-specific mechanical device.
摘要CTS-0103002 N。Seeman等人,纽约大学这一建议是在响应纳米科学与工程(NSE)招标,NSF-00119,在类别纳米跨学科研究团队(NIRT)。 这是纽约大学、加州理工学院和陶氏化学公司采用GOALI模式的合作活动。 目标是合成和演示可操作的纳米机器或设备。DNA系统提供的控制水平可以用来制造复杂的DNA纳米结构,包括形成二维和三维阵列的自组装DNA。 建模和仿真是该项目的关键部分,以构建和测试DNA纳米结构。建议将联合收割机与纽约大学、加州理工学院和陶氏化学实验室的活动结合起来,以实现基于DNA的纳米机械装置的演示,该装置可用于执行快速计算、用于检测环境中特定分子的传感器或用于改善材料的性质或性能。 纳米机器和器件的实际设计和制造需要克服合成、加工、表征、设计、优化和制造中的众多挑战。 该方法将首先通过计算对设计进行原型设计,优化特定的碱基对序列,确保特定的长度和间距将导致适当的间隙,并测试设备的操作,包括动力学。 该项目将重点关注三种类型的纳米机械设备。〇基于B-Z的纳米粒子。 一种基于DNA在不同盐条件下从B到Z DNA的转变的纳米晶体。 基于类似于DNA序列特异性机械装置的原理的基于DNA的开关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Nadrian Seeman其他文献
Nadrian Seeman的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Nadrian Seeman', 18)}}的其他基金
Multidimensional Materials Assembled by DNA Based Information
基于 DNA 的信息组装的多维材料
- 批准号:
1708776 - 财政年份:2017
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
Small: Collaborative Research: Programmed Cyclic Molecular Dancing on 2D Origami Lattices
小:合作研究:二维折纸晶格上的程序化循环分子跳舞
- 批准号:
1526650 - 财政年份:2015
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
AF: Small: Collaborative Research: Active DNA Assembly of Aperiodic Structures
AF:小型:合作研究:非周期结构的主动 DNA 组装
- 批准号:
1117210 - 财政年份:2011
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
Collaborative Research: EMT - Programmable Molecular Movements
合作研究:EMT - 可编程分子运动
- 批准号:
0726378 - 财政年份:2007
- 资助金额:
$ 150万 - 项目类别:
Continuing Grant
NIRT: Active Nanostructures for Nucleic Directed synthesis of Organic Functional Polymers
NIRT:用于有机功能聚合物核定向合成的活性纳米结构
- 批准号:
0608889 - 财政年份:2006
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
NANO: EMT: Revolutionary 3D Nanoarchitectures to Organize the Assembly of Computing Elements
NANO:EMT:用于组织计算元件组装的革命性 3D 纳米架构
- 批准号:
0523290 - 财政年份:2005
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
SGER: Feasibility Study of DNA-Directed Polymer Synthesis
SGER:DNA 定向聚合物合成的可行性研究
- 批准号:
0548774 - 财政年份:2005
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
Nano: Programmable Finite State Machines Achieved by DNA Self-Assembly
Nano:DNA自组装实现的可编程有限状态机
- 批准号:
0432009 - 财政年份:2004
- 资助金额:
$ 150万 - 项目类别:
Continuing Grant
Acquisition of an Atomic Force Microscope for DNA Nanotechnology Research and Education
购置原子力显微镜用于 DNA 纳米技术研究和教育
- 批准号:
0113879 - 财政年份:2001
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
相似海外基金
GOALI: Understanding granulation using microbial resource management for the broader application of granular technology
目标:利用微生物资源管理了解颗粒化,以实现颗粒技术的更广泛应用
- 批准号:
2227366 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: Development of Next Generation MXene-based Li-S Batteries with Practical Operating Temperatures
GOALI:开发具有实用工作温度的下一代 MXene 基锂硫电池
- 批准号:
2427203 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: Understanding Tribological Properties of Thermally-Synthesized Carbon
目标:了解热合成碳的摩擦学特性
- 批准号:
2315343 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: Understanding the Physical Mechanisms of Distortion and Controlling its Effects in Sintering-based Additive Manufacturing Processes
目标:了解变形的物理机制并控制其在基于烧结的增材制造工艺中的影响
- 批准号:
2328678 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: Integrated Design and Operability Optimization of Industrial-Scale Modular Intensified Systems
GOALI:工业规模模块化强化系统的集成设计和可操作性优化
- 批准号:
2401564 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
CPS: Medium: GOALI: Enabling Safe Innovation for Autonomy: Making Publish/Subscribe Really Real-Time
CPS:中:GOALI:实现自主安全创新:使发布/订阅真正实时
- 批准号:
2333120 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: Fundamental Investigation of Constrained Cutting for High Performance Machining of Difficult-to-Cut Materials
GOALI:难切削材料高性能加工约束切削的基础研究
- 批准号:
2323120 - 财政年份:2024
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: Frameworks: At-Scale Heterogeneous Data based Adaptive Development Platform for Machine-Learning Models for Material and Chemical Discovery
GOALI:框架:基于大规模异构数据的自适应开发平台,用于材料和化学发现的机器学习模型
- 批准号:
2311632 - 财政年份:2023
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
GOALI: ASCENT: Online Stability Assessment, Flexibility, and Enhancement of IBR-dominated Power Systems
目标:ASCENT:IBR 主导电力系统的在线稳定性评估、灵活性和增强
- 批准号:
2328248 - 财政年份:2023
- 资助金额:
$ 150万 - 项目类别:
Standard Grant
LEAP-HI: GOALI: Accelerating Design for Additive Manufacturing of Smart Multimaterial Devices
LEAP-HI:GOALI:加速智能多材料设备增材制造的设计
- 批准号:
2401218 - 财政年份:2023
- 资助金额:
$ 150万 - 项目类别:
Continuing Grant