NIRT: Biologically Based Assemblies of Electronic Materials at the Nanoscale; Improving on Nature

NIRT：纳米级电子材料的生物组装；

• 批准号: 0103473
• 负责人: Angela Belcher
• 金额: $ 150万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0103473&HistoricalAwards=false
• 关键词: NIRT; Biologically; Based; Assemblies; Electronic

AbstractCTS-0103473Angela Belcher, University of Texas AustinThis proposal was received in response to Nanoscale Science and Engineering (NSE) solicitation, NSF-00119, in the category Nanoscale Interdisciplinary Research Teams (NIRT). Biological systems efficiently and accurately assemble nanoscale building blocks into complexand functionally sophisticated structures with high perfection, controlled size and compositionaluniformity. The self-organizing processes found in these systems rely largely on non-covalent interactions that enable elegant rearrangement between usable architectural forms and self-correction. The research will take advantage of the atomic composition and plane specific recognition that a biomolecule can exhibit for an inorganic phase, and the nanostructural control and regularity that biomolecules typically impose on crystal phases and crystallographic orientations to control nanostructure formation. Furthermore, RNA templates will be used to direct the parallel self-assembly of multiple electronic components with high precision. Using combinatorial peptide evolution, peptide sequences will be identified that select for and bind to specific nanocrystal and nanowire substrates, such as magnetic and semiconductor quantum dots and silicon nanowires synthesized in solution. The peptides provide recognition specificity between the biological molecules and the inorganic substrate. The peptides couple the inorganic electronic "building blocks" to the biological machinery that directs the architectural "blueprints" for organization. In essence, genetically encoding biological-electronic interactions are selecting the mRNA sequences that code for specific amino acid sequences, but beyond that, specific secondary and ultimately tertiary structures can be achieved; thus, leading to supermolecular architectures. An interdisciplinary effort will include synthetic chemistry, electrical and materials engineering, and molecular biology, which targets the development of specific recognition chemistries between biological and inorganic substrates for the creation of nanostructured materials and devices with novel applications. The proposed project offers highly interdisciplinary educational and research opportunities for graduate students.

本文是在纳米尺度科学与工程（NSE）招标（NSF-00119）中，纳米尺度跨学科研究团队（NIRT）类别中收到的。生物系统高效、准确地将纳米级构建块组装成复杂、功能复杂的结构，具有高度的完美性、可控的尺寸和组成均匀性。在这些系统中发现的自组织过程很大程度上依赖于非共价相互作用，这种相互作用使可用的建筑形式和自我校正之间的优雅重新排列成为可能。该研究将利用生物分子对无机相的原子组成和平面特异性识别，以及生物分子对晶体相和晶体取向的纳米结构控制和规律性来控制纳米结构的形成。此外，RNA模板将用于指导多个电子元件的高精度并行自组装。利用组合肽进化，将识别选择并结合特定纳米晶体和纳米线衬底的肽序列，如磁性和半导体量子点以及溶液中合成的硅纳米线。肽提供生物分子和无机底物之间的识别特异性。多肽将无机电子“积木”与指导组织架构“蓝图”的生物机器结合起来。从本质上讲，基因编码生物电子相互作用是选择编码特定氨基酸序列的mRNA序列，但除此之外，可以实现特定的二级和最终三级结构；因此，导致了超分子结构。跨学科的努力将包括合成化学，电气和材料工程，以及分子生物学，其目标是开发生物和无机基质之间的特定识别化学，以创造具有新应用的纳米结构材料和器件。该项目为研究生提供了高度跨学科的教育和研究机会。