Protein Logic

蛋白质逻辑

• 批准号: 0103447
• 负责人: Joseph Lyding
• 金额: $ 115万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0103447&HistoricalAwards=false
• 关键词: Protein; Logic

Divisions of Chemistry, Molecular and Cellular Biosciences, Chemical Transport Systems, Computer-Communications Research, and Experimental and Integrated Activities support this multidivisional award to University of Illinois Urbana-Champaign. This Nanoscale Interdisciplinary Research Team (NIRT) award is part of the Nanoscale Science and Engineering program. Under this project, an interdisciplinary team with Joseph Lyding as the principal investigator will develop protein-based logic chips that interfaces between biochemical reactions and conventional microfabricated silicon-based electronics such as metal-oxide semiconductor (MOSFETs) taking advantage of biocomplexity and electronic speed. These protein interfaced MOSFETs will help to create atomically accurate protein arrays to function as cellular nonlinear/neural network, and this in turn will help to over come the 100 nm limit in miniaturization of the present transistor technology. Industrial collaborations and outreach programs in the K-12 system will be part of the project. Under the award, ordered and atomically accurate protein arrays that interfaces between biochemical reactions and conventional microfabricated silicon-based electronics will be developed. Strong industrial collaboration will help in the industrial development and technology transfer of this science. In addition, the research program will provide multidisciplinary education and training opportunities in materials chemistry, protein chemistry and electronics to students from K-12 to post doctoral candidates.

化学、分子和细胞生物科学、化学运输系统、计算机通信研究以及实验和综合活动部门支持伊利诺伊大学厄巴纳-香槟分校获得这一多部门奖项。这个纳米尺度跨学科研究团队（NIRT）奖是纳米尺度科学与工程计划的一部分。在这个项目下，一个由Joseph Lyding担任首席研究员的跨学科团队将开发基于蛋白质的逻辑芯片，该芯片将利用生物复杂性和电子速度的优势，将生化反应和传统的微制造硅基电子产品（如金属氧化物半导体（mosfet））连接起来。这些蛋白质接口mosfet将有助于创建原子精确的蛋白质阵列，作为细胞非线性/神经网络，这反过来将有助于克服目前晶体管技术小型化的100纳米限制。K-12系统的工业合作和推广计划将是该项目的一部分。根据该奖项，将开发有序和原子精确的蛋白质阵列，用于生物化学反应和传统微制造硅基电子产品之间的接口。强有力的工业合作将有助于这门科学的工业发展和技术转让。此外，该研究项目将为从K-12到博士后的学生提供材料化学、蛋白质化学和电子学等多学科的教育和培训机会。