Genetically Directed Syntheses of New Polymeric Materials

新型高分子材料的基因定向合成

• 批准号: 0110437
• 负责人: David Tirrell
• 金额: $ 39万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2004-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0110437&HistoricalAwards=false
• 关键词: Genetically; Directed; Syntheses; New; Polymeric

The statistical nature of step and chain growth polymerization processes ensures that the products of such reactions must be heterogeneous. Conventional p9olymeric materials therefore consist of complex mixtures of chains, often characterized by broad distributions of chain length, sequence and stereochemistry. In many materials applications, this kind of molecular heterogeneity is acceptable, and in some applications it is advantageous, insofar as it may suppress crystallization and preserve desirable properties such as optical clarity, elasticity or ease of processing. On the other hand, synthetic developments that have afforded improved control of macromolecular architecture, such as Ziegler-Natta catalysis and living polymerization, have had profound impact on polymer science and technology.%%%Over the past decade, several laboratories - including the PI's - have exploited the capacity of the protein biosynthetic apparatus of bacterial cells to make new macromolecular materials characterized by essentially complete control of molecular architecture. The most important advantages of this method appear to lie in two areas: i). In the integration of material properties with biological function, and ii). In the design and fabrication of small-scale structures (sometimes called nanostructures), in which uniformity of molecular architecture is critical. This proposal addresses the latter objective, with a specific focus on the assembly behavior of systems containing monodisperse macromolecular rods related to poly (g-benzyl a,L-glutamate) (PBLG). This research is co-funded by the Polymers Program in the Division of Materials Research and the Molecular Biochemistry Program in the Division of Molecular and Cellular Biosciences.***

步骤和链生长聚合过程的统计性质可确保此类反应的产物必须是异质的。 因此，常规的P9olymeric材料由链的复杂混合物组成，通常以链长，序列和立体化学的广泛分布为特征。 在许多材料应用中，这种分子异质性是可以接受的，在某些应用中，它是有利的，因为它可以抑制结晶并保留理想的特性，例如光学清晰度，弹性或易于处理。 另一方面，可以改善对大分子结构的控制的合成发展，例如Ziegler -Natta催化和生活聚合，对聚合物科学和技术产生了深远的影响。%% %%在过去的十年中，几个实验室（包括PI）（包括PI）（包括PI）通过蛋白质生物合成的材料的能力来剥削了蛋白质的材料，使得蛋白质生物合成的材料的能力是新实验室的能力。分子体系结构的控制。 该方法的最重要优势似乎在两个领域：i）。在将材料特性与生物功能的整合中，以及II）。在小型结构（有时称为纳米结构）的设计和制造中，其中分子结构的均匀性至关重要。 该提案针对后一个目标，特别关注包含与聚（G-苄基A，L-谷氨酸）（PBLG）的单分散大分子棒的系统的组装行为。 这项研究是由聚合物计划在材料研究划分和分子生物化学计划中共同资助的。*** ***