Purchase of a Liquid Chromatograph-Time-of-Flight Mass Spectrometer

购买液相色谱-飞行时间质谱仪

• 批准号: 0541745
• 负责人: David Tirrell
• 金额: $ 20.92万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0541745&HistoricalAwards=false
• 关键词: Purchase; Liquid; Chromatograph; Time; Flight

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multiuser Instrument Acquisition (CRIF:MU) Program, the Department of Chemistry and Chemical Engineering at California Institute of Technology will acquire a liquid chromatograph-time-of-flight mass spectrometry (LC-TOF) system. Representatives from the numerous projects that would take advantage of the new LC-TOF are the following: a) identification of the metabolites of libraries of novel cytochromes P450 that are generated by methods of directed evolution; b) identification and quantification of the oligomeric components of aerosols with the aim of understanding their global impact on health and climate; c) identification of the chemical composition of the atmosphere of Titan, the largest moon of Saturn; d) guided organic synthesis where complex bioactive molecules are synthesized by novel, and more efficient pathways; and e) identification and quantification of new bioactive molecules in plants with interesting pharmacological properties. Liquid chromatography with mass spectrometric detection is an extremely powerful technique used for the separation and analysis of complex mixtures. In addition to providing analytical support for a broad range of exciting scientific problems, the new LC-TOF will play a more important educational role. First is the enhancement of the current educational and research activities of the graduate students and post-docs who will receive mass spectrometric training and gain ready access to this new LC-TOF to implement their research. Second and more importantly, is the enhancement of the learning experiences of the undergraduates who participate in the Summer Undergraduate Research Fellowship and Minority Undergraduate Research Fellowship programs. These programs sponsor talented undergraduates to spend a summer working in a research lab on the Caltech campus, and those whose projects require mass spectroscopy will receive training and hands-on experience at this facility.

通过化学研究仪器和设施的奖项：部门多用器仪器获取（CRIF：MU）计划，加利福尼亚理工学院化学和化学工程系将获得液态色谱仪质谱法（LC-TOF）系统。来自众多项目利用新LC-TOF的代表如下：a）鉴定通过有向进化方法生成的新型细胞色素P450库的代谢物； b）鉴定和量化气溶胶的寡聚成分，目的是了解其全球对健康和气候的影响； c）鉴定土星最大的月亮泰坦大气的化学成分； d）具有指导性的有机合成，其中复杂的生物活性分子是通过新颖和更有效的途径合成的； e）具有有趣的药理特性的植物中新生物活性分子的鉴定和定量。具有质谱检测的液相色谱法是一种非常强大的技术，用于分离和分析复杂混合物。 除了为各种令人兴奋的科学问题提供分析支持外，新的LC-TOF还将发挥更重要的教育作用。首先是增强研究生和研究生的当前教育和研究活动，这些活动将接受质谱培训，并准备好访问这一新的LC-TOF以实施他们的研究。其次，更重要的是，加强了参加夏季本科研究奖学金和少数群体本科研究奖学金计划的本科生的学习经历。这些计划赞助了有才华的本科生在Caltech校园的研究实验室工作的夏天，而这些项目需要质谱的项目将在此设施中获得培训和动手经验。