Purchase of a Liquid Chromatograph-Time-of-Flight Mass Spectrometer

购买液相色谱-飞行时间质谱仪

• 批准号: 0541745
• 负责人: David Tirrell
• 金额: $ 20.92万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0541745&HistoricalAwards=false
• 关键词: Purchase; Liquid; Chromatograph; Time; Flight

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multiuser Instrument Acquisition (CRIF:MU) Program, the Department of Chemistry and Chemical Engineering at California Institute of Technology will acquire a liquid chromatograph-time-of-flight mass spectrometry (LC-TOF) system. Representatives from the numerous projects that would take advantage of the new LC-TOF are the following: a) identification of the metabolites of libraries of novel cytochromes P450 that are generated by methods of directed evolution; b) identification and quantification of the oligomeric components of aerosols with the aim of understanding their global impact on health and climate; c) identification of the chemical composition of the atmosphere of Titan, the largest moon of Saturn; d) guided organic synthesis where complex bioactive molecules are synthesized by novel, and more efficient pathways; and e) identification and quantification of new bioactive molecules in plants with interesting pharmacological properties. Liquid chromatography with mass spectrometric detection is an extremely powerful technique used for the separation and analysis of complex mixtures. In addition to providing analytical support for a broad range of exciting scientific problems, the new LC-TOF will play a more important educational role. First is the enhancement of the current educational and research activities of the graduate students and post-docs who will receive mass spectrometric training and gain ready access to this new LC-TOF to implement their research. Second and more importantly, is the enhancement of the learning experiences of the undergraduates who participate in the Summer Undergraduate Research Fellowship and Minority Undergraduate Research Fellowship programs. These programs sponsor talented undergraduates to spend a summer working in a research lab on the Caltech campus, and those whose projects require mass spectroscopy will receive training and hands-on experience at this facility.

根据化学研究仪器和设施：部门多用户仪器采购（CRIF:MU）计划的这份合同，加州理工学院化学和化学工程系将获得一套液相色谱-飞行时间质谱（LC-TOF）系统。将利用新的LC-TOF的众多项目的代表如下：a)鉴定由定向进化方法产生的新型细胞色素P450文库的代谢物；(B)鉴定和定量气溶胶的低聚组分，以了解其对健康和气候的全球影响；c)确定土卫六（土星最大的卫星）大气的化学成分；D)引导有机合成，通过新颖、更有效的途径合成复杂的生物活性分子；e)鉴定和定量植物中具有有趣药理特性的新生物活性分子。液相色谱与质谱检测是一种非常强大的技术，用于分离和分析复杂的混合物。除了为一系列令人兴奋的科学问题提供分析支持外，新的LC-TOF将发挥更重要的教育作用。首先是加强研究生和博士后目前的教育和研究活动，他们将接受质谱培训，并准备好进入这个新的LC-TOF来实施他们的研究。第二，也是更重要的，是提高参加暑期本科生研究奖学金和少数民族本科生研究奖学金项目的本科生的学习经验。这些项目资助有才华的本科生在加州理工学院校园的一个研究实验室度过一个夏天，那些项目需要质谱的人将在这个设施接受培训和实践经验。