Natural Organometallic Catalytic Sites: H2-Activating Metalloenzymes

天然有机金属催化位点：H2 激活金属酶

• 批准号: 0111629
• 负责人: Marcetta Darensbourg
• 金额: $ 45万
• 依托单位: Texas A&M Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0111629&HistoricalAwards=false
• 关键词: Natural; Organometallic; Catalytic; Sites; H2

The Inorganic, Bioinorganic and Organometallic Chemistry Program of the Division of Chemistry, National Science Foundation, supports the work of Dr. Marcetta Darensbourg (Department of Chemistry at Texas A&M) directed at delineating structure/function relationships for Ni/Fe and Fe-only hydrogenase enzymes through the use of synthetic model systems. Specifically, the PI (i) will develop synthetic routes to amine-containing S--S bridges in iron carbonyl compounds, (ii) will use functionalized diphosphine ligands as "models of the models" for the hydrogenase active site, (iii) will explore the hydrogen activation chemistry of (-SR'S)Fe2(CO)6 compounds that possess a functionalized S--S bridge, and (iv) will explore the organometallic chemistry relevant to active site cluster synthesis for the hydrogenase enzyme.Students mentored by Prof. Darensbourg are poised to make a real and significant contribution to the scientific infrastructure of the country. Their work will have a lasting impact on both the biochemical and chemical communities. The results will help in initiating efforts to design a cheaper industrial process to produce hydrogen, a potential clean source of energy.

美国国家科学基金会化学部的无机、生物无机和有机金属化学项目支持Marcetta Darensbourg博士（德克萨斯农工大学化学系）通过使用合成模型系统来描述Ni/Fe和纯铁氢化酶的结构/功能关系。具体而言，PI (i)将开发铁羰基化合物中含胺S—S桥的合成路线，（ii）将使用功能化二膦配体作为氢化酶活性位点的“模型模型”，（iii）将探索具有功能化S—S桥的（-SR'S）Fe2(CO)6化合物的氢活化化学，（iv）将探索与氢化酶活性位点簇合成相关的有机金属化学。由Darensbourg教授指导的学生准备为该国的科学基础设施做出真正和重大的贡献。他们的工作将对生物化学和化学界产生持久的影响。研究结果将有助于设计一种更便宜的工业生产氢气的方法，这是一种潜在的清洁能源。