US-Egypt Cooperative Research: Microsphere Based Tissue Engineering

0115595 Laurencin描述：该奖项是为了支持化学工程教授卡托·Laurencin博士、德雷克塞尔大学化学工程系研究助理教授Mohamed Attawia博士和埃及开罗国家研究中心（NRC）陶瓷系Wafaa Ismail博士的合作项目。 他们计划开发和研究用于骨组织工程的新型三维基质。 这些基质是在Drexel开发的，基于聚合物微球，证明了体外骨附着和生长以及体内矿化中细胞向内生长的能力。 NRC研究人员的工作已经证明了壳聚糖支持成骨细胞和其他间充质细胞生长和表型表达的能力。 近年来，对壳聚糖化学改性和壳聚糖络合作用的研究产生了具有一系列物理化学性质的新材料。 研究人员计划研究由壳聚糖制成的组织工程基质的微球基质和使用可降解聚合物材料与壳聚糖复合物组合的组织工程微球基质。适用范围：该奖项将允许美国和埃及科学家在聚合物和生物材料方面具有互补能力和研究经验的合作。 这两位美国科学家在各自的领域都很杰出，在与该问题相关的领域发表了大量文章。 埃及合作者是一位活跃的研究人员，在陶瓷，聚合物和生物材料方面拥有技能和专业知识。 一名美国学生和一名埃及学生将参与这项研究，并将从国际合作中获得经验。 该研究课题对材料科学（特别是生物材料）界和医学界都具有广泛的兴趣。 这一建议符合INT在互利领域加强国际科学合作的目标。 该项目得到生物工程和环境系统司以及国际方案司的支持。

0115595LaurencinDescription: This award is for support of a cooperative project by Dr. Cato Laurencin, Professor of Chemical Engineering, and Dr. Mohamed Attawia, Research Assistant Professor, Department of Chemical Engineering, Drexel University, and Dr. Wafaa Ismail, Department of Ceramics at the National Research Center (NRC), in Cairo, Egypt. They plan to develop and study novel three-dimensional matrices useful for tissue engineering of bone. These matrices, developed at Drexel and based on polymeric microspheres, demonstrate the ability to allow for attachment and growth of bone in vitro and cellular ingrowth in mineralization in vivo. Work by researchers at the NRC has demonstrated the ability of chitosan to support the growth and phenotypic expression of osteoblasts and other mesenchymal cells. Recent research for the modifications of chitosan chemistry and chitosan complexation resulted in new materials with ranges of physicochemical properties. The investigators plan to study microsphere based matrices for tissue engineered matrices made from chitosan and microsphere based matrices for tissue engineering using degradable polymeric materials combined with chitosan based complexes. Scope: This award will permit collaboration between US and Egyptian scientists who have complementary capabilities and research experience in polymers and biomaterial. The two US scientists are eminent in their field and are highly published in areas related to the problem. The Egyptian collaborator is an active researcher with skills and expertise in ceramics, polymers, and biomaterials. One US student and one Egyptian student will participate in this research and will gain experience from the international collaboration. The research topic is of broad interest both to the materials science (especially biomaterials) community and to the medical science community. This proposal meets the INT objective of increasing international scientific collaboration in areas of mutual benefit. The project is supported by the Division of Bioengineering and Environmental Systems and the Division of International Programs.