EFRI BioFlex: Electrically Mediated Complex Tissue Regeneration

EFRI BioFlex：电介导的复杂组织再生

• 批准号: 1332329
• 负责人: Cato Laurencin
• 金额: $ 200万
• 依托单位: University of Connecticut Health Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2025-07-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1332329&HistoricalAwards=false
• 关键词: EFRI; BioFlex; Electrically; Mediated; Complex

The proposal focuses on the creation of novel, electrically-stimulated, bioresorbable electrospun polymeric scaffolds capable of accelerating regeneration of musculoskeletal tissue, with a focus on rotator cuff healing. Tissue engineering has been applied to individual tissues like bone, ligament, tendon, cartilage, muscle, nerve, and blood vessels with a degree of success in the clinical realm. The complex task of full limb regeneration has been left to developmental biologists often studying invertebrates capable of self-regeneration. Lessons learned from scaffold-based tissue engineering can, when blended with developmental and stem cell-based biology and electrical engineering, be applied to the regeneration of complex organs and tissues. This construct will be structured and fine-tuned based on polyphosphazene chemistry, fiber size, and fiber orientation to create an electrically conductive scaffold that exhibits region-specific mechanical properties that mimic those seen in a native muscle-tendon interface. The system will be tested in a rabbit model in which the subscapularis tendon will be transected from the bone with or without transecting the subscapular nerve.

该提案的重点是创造新型的，电刺激的，生物可吸收的静电纺丝聚合物支架，能够加速肌肉骨骼组织的再生，重点是肩袖愈合。组织工程已应用于单个组织，如骨、韧带、肌腱、软骨、肌肉、神经和血管，在临床领域取得了一定程度的成功。完整肢体再生的复杂任务留给了发育生物学家，他们经常研究能够自我再生的无脊椎动物。从基于支架的组织工程学中吸取的经验教训，当与基于发育和干细胞的生物学和电气工程相结合时，可以应用于复杂器官和组织的再生。该结构将基于聚磷腈化学、纤维尺寸和纤维取向进行结构化和微调，以产生具有区域特异性机械性能的导电支架，该区域特异性机械性能模拟天然肌肉-肌腱界面中所见的机械性能。将在家兔模型中对该系统进行测试，在该模型中，将肩胛下肌腱从骨上横切，伴或不伴肩胛下神经横切。