FOR 1363: Biogenic Amines in Insects: Coordination of Physiological Processes and Behaviour

生物胺是一种经典的递质，是神经调节剂和神经激素，存在于所有动物物种中，包括脊椎动物和无脊椎动物，包括人类。生物胺属于递质，在生物进化早期就出现，并在类似的生理环境中反复使用。在人类中，严重的疾病如帕金森病或精神病都是由生物胺引起的。由于昆虫具有良好的实验可及性，因此可以在不同水平上研究生物胺：(1)在分子水平上，就生物胺受体分子及其与细胞内信号通路的关联而言；(2)在细胞水平上，就释放生物胺的神经元及其靶组织或靶神经元而言；(3)在系统-有机体水平上，就整个神经元网络而言，受生物胺影响；(4)就行为过程而言，在行为水平上，生物胺起着关键作用。研究股的目的是弥合不同层次，从而更全面地了解生物胺的作用。

Biogenic amines act as classical transmitter, as neuromodulators and neurohormones and are found in all animal species, both of vertebrates and invertebrates, including humans. Biogenic amines belong transmitters, which appear early during evolution of organisms and are used repeatedly in similar physiological contexts. In humans severe pathologies such as Parkinson or psychotic disease are caused by biogenic amines. Due to their favourable experimental accessability, insects allow to study biogenic amines at different levels: (1) at a molecular level as far as biogenic amine receptor molecules and their association with intracellular signalling pathways are concerned, (2) at a cellular level as far as the neurons are concerned, which release biogenic amines and their target tissues or target neurons, (3) at a systemic-organismic level as far as whole networks of neurons are concerned, which are influenced by biogenic amines, and (4) at a behavioural level as far as behavioural processes are concerned in which biogenic amines play a key function. The aim of the Research Unit is to bridge the different level and, thus, come to a more complete understanding of biogenic amine action.