Genome sequence of a Streptococcus dysgalactiae subsp. equisimilis, possessing the group A carbohydrate cell wall antigen, and its comparative genomics

停乳链球菌亚种的基因组序列。

• 批准号: 151655513
• 负责人: Professor Dr. Rudolf Lütticken
• 金额: --
• 依托单位: DWI - Leibniz-Institut für Interaktive Materialien e.V.
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/151655513?language=en
• 关键词: Genome; sequence; Streptococcus; dysgalactiae; subsp.

Streptococcus dysgalactiae subspecies equisimilis (Sde) is a human pathogen causing a variety of infections from mild pharyngitis to severe sepsis possibly including cases of toxic shock syndrome. This beta-hemolytic Streptococcus species apparently is closely related to another even more serious human pathogen, Streptococcus pyogenes, carrying the group A carbohydrate cell wall antigen (therefore also referred as Group A Streptococcus or GAS). S. dysgalactiae subsp. equisimilis mostly possesses either the group C or the group G antigen (therefore referred to as GCS or GGS). This project will result in the first complete genome of a Streptococcus dysgalactiae subsp. equisimilis strain possessing the group A antigen. The genomic data obtained and a comparative genomic study with other completed streptococcal genomes, especially from S. pyogenes and groups C and G streptococci of animal origin will result in very useful information on the properties essential for the pathogenicity of beta-hemolytic streptococci causing disease in humans. It will also provide highly wanted data for the development of vaccines directed against diseases caused by beta-hemolytic streptococci.

等乳链球菌亚种(SDE)是一种人类致病菌，可引起从轻度咽炎到严重败血症的多种感染，可能包括中毒性休克综合征。这种β-溶血性链球菌显然与另一种更严重的人类病原体--化脓性链球菌密切相关，它携带A组碳水化合物细胞壁抗原(因此也被称为A组链球菌或GAS)。异乳链霉菌亚种。等同种病毒大多具有C群或G群抗原(因此称为GCS或GGS)。该项目将产生第一个完整的半乳链球菌亚种基因组。具有A组抗原的等同菌株。获得的基因组数据以及与其他完整的链球菌基因组的比较基因组研究，特别是来自化脓性链球菌和动物来源的C和G群链球菌的基因组研究，将为人类致病的β-溶血性链球菌的致病特性提供非常有用的信息。它还将为开发针对贝塔溶血性链球菌引起的疾病的疫苗提供急需的数据。