QSB: Quantitative Analysis and Studies of the Correlation Between mRNA and Protein Expression Profiles in E. coli

QSB：大肠杆菌 mRNA 和蛋白质表达谱之间相关性的定量分析和研究

• 批准号: 0120315
• 负责人: Kelvin Lee
• 金额: $ 28.37万
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2005-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0120315&HistoricalAwards=false
• 关键词: QSB; Quantitative; Analysis; Studies; Correlation

The aim is to develop a meaningful mathematical description of translation, which can provide insights into the mRNA-protein expression relationship in Escherichia coli. The two overarching objectives of the proposed efforts are: (i) the identification of the parameters that affect the correlation of mRNA and protein expression based on the formulation and computational analysis of mathematical models of the translation processes, and (ii) the quantification of these parameters using the information derived within the experimental component of the proposed work.

目的是建立一种有意义的翻译数学描述，这可以为了解大肠杆菌中mrna -蛋白的表达关系提供见解。所提议的工作的两个总体目标是：(i)基于翻译过程数学模型的公式和计算分析确定影响mRNA和蛋白质表达相关性的参数，以及（ii）使用所提议工作的实验组成部分中导出的信息对这些参数进行量化。