IGERT: Systems Biology of Cells in Engineered Environments (SBE2)

IGERT：工程环境中细胞的系统生物学 (SBE2)

• 批准号: 1144726
• 负责人: Kelvin Lee
• 金额: $ 182.02万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1144726&HistoricalAwards=false
• 关键词: IGERT; Systems; Biology; Cells; Engineered

This Integrative Graduate Education and Research Traineeship (IGERT) award facilitates the unique interdisciplinary training of Ph.D. scientists and engineers in the field of biotechnology by elucidating how cells interact with specifically designed environments based on a broad understanding of changes in the molecules within cells. Trained students will be ready to address a wide range of problems facing society, from agriculture and energy to human health and medicine. Intellectual Merit: This program addresses this challenge by focusing on two areas of importance in biotechnology: cells' behaviors based on growth in a variety of environments; and "systems biology" - the integrated analysis of numerous molecular changes, particularly those related to gene expression, that occur within cells when exposed to different environments. A key feature of this work is that the environments will be specifically engineered. For example, different materials will be used to support the growth of a particular type of cell. By studying the impact of these controlled environments on the expression of the cell?s genes, one can begin to design strategies to target specific environments for specific applications: growth of cells as tissue replacement for healing, and design of better ways to deliver medicines, among others. The cross-training effort synergizes diverse areas of expertise available at the University of Delaware. Broader Impacts: This program addresses a critical question related to biotechnology research: how do molecular changes within a cell relate to the environment in which the cell is exposed? There are many important application areas and our program will provide students with an opportunity to learn critical experimental and computational techniques to best prepare them for careers in the life sciences industry. An emphasis on innovation will provide students with an opportunity to engage in industry internships and public policy, intellectual property workshops, as well as research experiences at institutions around the world. We will work to develop programs that broaden minority participation at multiple levels.IGERT is an NSF-wide program intended to meet the challenges of educating U.S. Ph.D. scientists and engineers with the interdisciplinary background, deep knowledge in a chosen discipline, and the technical, professional, and personal skills needed for the career demands of the future. The program is intended to establish new models for graduate education and training in a fertile environment for collaborative research that transcends traditional disciplinary boundaries, and to engage students in understanding the processes by which research is translated to innovations for societal benefit.

这个综合研究生教育和研究培训（IGERT）奖促进了博士的独特的跨学科培训。生物技术领域的科学家和工程师通过阐明细胞如何与基于对细胞内分子变化的广泛理解而专门设计的环境相互作用。经过培训的学生将准备解决社会面临的各种问题，从农业和能源到人类健康和医学。智力优势：该计划通过专注于生物技术中的两个重要领域来解决这一挑战：基于在各种环境中生长的细胞行为;和“系统生物学”-对许多分子变化的综合分析，特别是那些与基因表达相关的分子变化，当暴露于不同环境时细胞内发生。这项工作的一个关键特征是环境将被专门设计。例如，不同的材料将用于支持特定类型细胞的生长。通过研究这些受控环境对细胞表达的影响？基因，人们可以开始设计策略，针对特定的应用特定的环境：细胞的生长作为愈合的组织替代品，以及设计更好的方式来提供药物，等等。交叉培训的努力协同不同领域的专业知识可在特拉华州的大学。更广泛的影响：该计划解决了与生物技术研究相关的一个关键问题：细胞内的分子变化如何与细胞暴露的环境相关？有许多重要的应用领域，我们的计划将为学生提供学习关键实验和计算技术的机会，以最好地为他们在生命科学行业的职业生涯做好准备。强调创新将为学生提供参与行业实习和公共政策，知识产权研讨会以及世界各地机构研究经验的机会。我们将努力开发在多个层面扩大少数族裔参与的项目。IGERT是一个全NSF范围的项目，旨在应对美国博士教育的挑战具有跨学科背景的科学家和工程师，在所选学科的深厚知识，以及未来职业需求所需的技术，专业和个人技能。该计划旨在为研究生教育和培训建立新的模式，为超越传统学科界限的合作研究创造肥沃的环境，并让学生了解研究转化为创新以造福社会的过程。