Instrumental Methods Across the Chemistry Curriculum with Emphasis on Macromolecular Structure Studies

化学(12)我们正在通过调整和实施我们的化学和生物化学课程项目来加强我们的本科课程，这些项目利用了我们新获得的CD光谱偏振仪。我们的主要重点是开发一门综合的生物物理化学实验课程，该课程包括一系列项目，重点是使用CD仪器研究大分子结构和功能。我们还将CD仪器集成到我们的二年级和更高级别的实验室以及正在进行的师生研究项目中。以项目为基础的生物物理实验室是用仪器手段研究大分子结构和功能的论坛。多肽和DNA结构的各个方面正在使用CD光谱仪进行检查。在有机化学二年级，学生使用CD仪器来确定手性化合物的绝对构型。此外，我们正在改编J.Chem的一个以项目为导向的实验。电学。我们的高等有机化学专业的学生在完成有机金属合成后，使用CD仪器来确定α-氨基酸的绝对构型。结合我们的200 MHz核磁共振和UV/Vis分光光度计，生物物理化学课程的学生可以研究蛋白质和DNA结构的热力学。我们项目的总体目标是通过结合现代仪器来提高学生在化学和生物化学方面的问题解决能力，并使他们能够寻求解决科学问题的不同方法。

Chemistry (12)We are enhancing our undergraduate curriculum by adapting and implementing into our chemistry and biochemistry courses projects which make use of our newly acquired CD spectropolarimeter. Our primary emphasis is to develop an integrated biophysical chemistry laboratory course that involve a series of projects focused on the investigation of macromolecular structure and function using the CD instrumentation. We are also integrating CD instrumentation into our sophomore and higher level laboratories and in ongoing student-faculty research projects. The project-based biophysical laboratory represents a forum for investigation of macromolecular structure and function by instrumental means. Aspects of polypeptide and DNA structure are being examined using the CD spectrometer. In sophomore Organic chemistry, students use the CD instrumentation to determine the absolute configuration of chiral compounds. Additionally, we are adapting a project-oriented experiment from the J. Chem. Educ. in which our students in advanced organic chemistry use the CD instrumentation to determine the absolute configuration of alpha amino acids following completion of an organometallic synthesis. Coupled with our 200 MHz NMR and the UV/vis spectrophotometer, students in the biophysical chemistry course investigate the thermodynamics of protein and DNA structures. The overarching goal of our project is to enhance our students' problem solving skills in chemistry and biochemistry through incorporation of modern instrumentation and to enable them to seek varied approaches to the solution of scientific problems.